【正文】
onse to stress. A healthy individual will produce cortisol throughout the day, following a diurnal pattern, with peak levels once a day. 糖皮質(zhì)激素分泌的晝夜節(jié)律性 下丘腦垂體腎上腺皮質(zhì)調(diào)節(jié)系統(tǒng) HPA axis 吸收 :口服、注射均易吸收;局部用藥大量可致全身作用 . 分布 : 90%與血漿蛋白結(jié)合( 80%與皮質(zhì)激素轉(zhuǎn)運球蛋白結(jié)合, 10%與白蛋白結(jié)合),10%為游離型;肝、腎疾病時,游離型GC增加。 ① 調(diào)節(jié)機體的主要物質(zhì)代謝; ② 調(diào)控機體器官的發(fā)育和功能; ③ 參與機體的應(yīng)激反應(yīng),維持機體內(nèi)環(huán)境平衡; 皮質(zhì)激素 是由腎上腺皮質(zhì)細(xì)胞分泌的一類具有甾體母核的生物活性物質(zhì)的總稱。 第二十九章 腎上腺皮質(zhì)激素類藥物 Adrenocortical Hormone Agents 激素: 為所有內(nèi)分泌腺體所分泌的生物活性物質(zhì)。 具有作用強大、活性高、用量小,具有廣泛的生理調(diào)節(jié)作用。 There are two adrenal glands in your body, one on top of each kidney. Each consists of two parts: an outer layer, the cortex, and an inner area, the medulla. Both parts produce important hormones the body needs. The cortex produces hormones that control blood pressure, salt and potassium levels and the body’s use of fats, proteins and carbohydrates. The cortex also makes male sex hormones. The medulla produces adrenaline and other hormones that affect blood pressure, heart rate and sweating. 腎上腺結(jié)構(gòu)與功能示意圖 腎上腺皮質(zhì)激素分類 (Adrenocortical hormones)甾體類化合物 鹽皮質(zhì)激素 — 球狀帶分泌 (醛固酮;去氧皮質(zhì)酮等) 糖皮質(zhì)激素 — 束狀帶分泌 (氫化可的松;可的松等)