生物化學(xué)簡(jiǎn)明教程第四版第九章糖代謝二-展示頁
2025-01-25 13:59本頁面
【正文】 脫氫酶 Mn2+ (3)α酮戊二酸的生成 異檸檬酸脫氫酶特性： 1） 具有脫氫和脫羧兩種功能，脫羧反應(yīng)需要 Mn2+； 2）是別構(gòu)酶： ADP是激活劑； ATP和 NADH是抑制劑。 檸檬酸合酶 ()活性受 ATP、 NADH、琥珀酸 CoA等抑制。葡萄糖 → → → 丙酮酸 → 乙酰 CoA → → → CO2+H2O 糖的有氧分解 檸檬酸循環(huán) (三羧酸循環(huán) ) (線粒體 ) 糖酵解 (細(xì)胞質(zhì) ) 丙酮酸的氧化 (線粒體 ) 丙酮酸的氧化 丙酮酸脫氫酶系 (線粒體膜上 ) 酶的組分 丙酮酸脫羧酶 硫辛酸乙酰移換酶 二氫硫辛酸脫氫酶 輔因子 TPP 硫辛酸 HSCoA NAD+ Regulation of the pyruvate dehydrogenase plex. The plex is inhibited by its immediate products, NADH and acetyl CoA. The pyruvate dehydrogenase ponent is also regulated by covalent modification. A specific kinase phosphorylates and inactivates pyruvate dehydrogenase, and a phosphatase actives the dehydrogenase by removing the phosphoryl. The kinase and the phosphatase also are highly regulated enzymes. 丙酮酸脫氫酶系活性的調(diào)控 Why does TPP deficiency lead primarily to neurological disorders? The nervous system relies essentially on glucose as its only fuel. In contrast, most other tissues can use fats as a source of fuel for the citric acid cycle. The product of aerobic glycolysis, pyruvate, can enter the citric acid cycle only through the pyruvate dehydrogenase plex. 丙酮酸代謝的中斷 腳氣病以及汞、砷中毒的原因？ Arsenite poisoning. Arsenite inhibits the pyruvate dehydrogenase plex by
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