cik細(xì)胞免疫治療在惡性腫瘤中的應(yīng)用-盧學(xué)春-文庫吧資料
2024-08-08 07:01本頁面
【正文】 in. 06 2100101102103104C D 3 Pe rC P03 z ha ng b in. 06 2100101102103104C D 3 Pe rC P03 z ha ng b in. 06 2100101102103104C D 8 PE03 z ha ng b in. 06 2express both the Tcell marker CD3 and natural killer cell marker CD56 and nonMHCrestricted CIK cells have intercellular adhesion moleculel (ICAMl). CIK CIK cells possess cytoplasmic granules, which contain the protein perforin (cytolysin). CIK cells are effective against FasLpositive malignant cells and cells with multidrug resistance (MDR) CIK cells can themselves secrete many cytokines, such as IL2, TNF a, GMCSF and so on. CIK cells migrated to tumor sites by the 7th hour after injection and remained detectable at these sites for an additional 9 days CIK免疫細(xì)胞的抗腫瘤機(jī)制 CIK免疫細(xì)胞的制備 細(xì)胞接種數(shù) 2 106/ml , IFNr 1000u/ml Ficoll 分離，回收 PBMC Il IL1a 、 antiCD3McAb 各1000u/ml 抽血： 50ml 擴(kuò)增培養(yǎng)， 2天換液， IL2持續(xù)培養(yǎng) 收集細(xì)胞，回輸患者體內(nèi) 3d 抽血： 50ml 1d 2d 14d 培養(yǎng)擴(kuò)增前后淋巴細(xì)胞總數(shù)及比例變化
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