腎上腺素受體激動(dòng)藥-文庫(kù)吧資料
2024-10-25 17:32本頁(yè)面
【正文】 be given iv or im Therapeutic Uses ? cardiac arrest ? anaphylactic shock ? Asthma and acute hypersensitivity reaction ? prolong the duration of local anesthesia ? Glaua Adverse Effects ? Palpitation, headache ? BP , arrhythmia ? Hypertension, diabetes mellitus, hyperthyroidism Drug interactions ? General anesthetics ? Psychotropic drugs ? βblockers Ephedrine ? absorbed when taken orally ? CNS effects may occur: such as insomnia, nervousness, nausea and agitation ? resistant to COMT and MAO, so that its action is prolonged ? Little effect on metabolism ? Acute tolerance pharmacological Effects ? Cardiac output , HR ? Blood vessel ? Blood pressure ? Relax smooth muscle ? skeletal muscle ? CNS: excitement ? Tachyphylaxis Clinical Uses ? Bronchial asthma ? Nasal decongestant ? Hypotension without crisis ? Adverse reactions: CNS Dopamine ? activate α、 β1 and dopareceptor ? Be metabolized by MAO and COMT quickly ? No effect on CNS Dopamine ? Blood vessels – At low or intermediate concentration: act on D1 receptor, dilate – At high concentration : act on αreceptor, constrict ? Heart: positive inotropic effect on the myocardium, increase cardiac output Pharmacological Effects ? Kidney – At low or intermediate concentration: reduce arterial resistance in the mesentery and kidney – At high concentrat
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