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chapter38macrolides,lincomycinsandpolymycins(參考版)

2024-10-03 21:59本頁面
  

【正文】 neurotoxicity Baciteracin ? Active against grampositive bacteria ? Inhibit cell wall formation ? No crossresistance with other agents ? Topical use only because of nephrotoxicity 。 Teicoplanin ?Polymyxins ?bactitracin Vanycin ? Mechanism of action ? Inhibit cell wall synthesis ? Antimicrobial spectrum: ? Narrow spectrum, active only against grampositive bacteria paticularly staphylococci ? Pharmacokiics ? Poorly absorbed from intestinal tract, iv ? Excreted from glomerular filtration 90% Vanycin ? Clinical uses ? Infection caused by MRSA, MRSE and penicillinresistant pneumococcus ? Treatment of antibioticassociated enterocolitis caused by clostridium difficile po ? Adverse reaction ? Ototoxicity amp。 azithromycin: bile ? Clarithromycin: kidney Commomly used macrolides Erythromycin ? Antimicrobial activity ? Grampositive anisms: pneumococci, streptococci, staphylococci , diphtheriae etc ? Gramnegative anisms:legi
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