chapter38macrolides,lincomycinsandpolymycins(編輯修改稿)
2024-11-04 21:59 本頁(yè)面
【文章內(nèi)容簡(jiǎn)介】 Liver toxicity ? Cardiotoxicity Erythromycin ? Erythromycin lactobionate(乳糖酸紅霉素） ? erythromycin estolate（無(wú)味紅霉素 ) ? erythromycin stearate(硬脂酸紅霉素） ? erythromycin ethylsuccinate（琥乙紅霉素， 利君沙 ） New macrolides antibiotics ? Advantage : ? Broader spectrum, higher activity ? Orally effective ? High blood concentration ? Longer t 1/2 ? Less toxicity ? Mainly used in respiratory tract infection Clarithromycin（甲紅霉素 ,克拉霉素） ? Has the strongest activity on Grampositive bacteria, legionella pneumophila, chlamydia pneumoniae and ? Good pharmacokiic property ? Low toxicity Azithromycin (阿齊霉素 ,麗珠奇樂(lè)） ? Has the strongest activity against mycoplasma pneumoniae（肺炎支原體） ? More effective on Gramnegative bacteria ? Well tolerated ? T1/2 :35~48h once daily ? Mainly used in respitory tract infection Roxithromycin （羅紅霉素，嚴(yán)迪） ? 1987 France ? The highest blood concentration
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