chapter38macrolides,lincomycinsandpolymycins-wenkub.com
2024-09-25 21:59 本頁(yè)面
【正文】 nephrotoxicity ? Redman syndrome Teicoplanin ? Similar to vanycin in mechanism and antimicrobial spectrum ? Can be given im as well as iv ? Less adverse reactions Polymyxins ? Active only against gramnegative rods, particularly ? Mechanism:increase permeability of cell membrane ? Mainly used in infection when other drugs are resistant ? Toxicity: nephrotoxicity amp。clarithromycin: in liver ? Excretion ? Erythromycinamp。 azithromycin: bile ? Clarithromycin: kidney Commomly used macrolides Erythromycin ? Antimicrobial activity ? Grampositive anisms: pneumococci, streptococci, staphylococci , diphtheriae etc ? Gramnegative anisms:legionella（軍團(tuán)菌） ,bacillus pertussis(百日咳 ), brucella(布氏 ) , meningococci, diplococcus gonorrhoeae etc ? Others: mycoplasma(支原體 ), chlamydia trachomatis(沙眼衣原體 ), rickettsia(立克次體 ), spirochete ,anaerobes etc. Erythromycin ?Clinical uses ? As penicillin substitute in penicillinallergic or re
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