代表講稿2-doripenem-anewbroa-資料下載頁
2025-02-21 14:30本頁面
【正文】 et prospects In clinical trials, doripenem was welltolerated. The most adverse events seen were diarrhea, nausea, constipation, urinary tract infection and decubitus ulcer, monly known as a bedsore. Market prospects The current global situation of antiinfective market: antiinfective drug market sales account for about 15% of total sales, that is, the second of the global pharmaceutical market . Among them, antibiotics make the largest share, about 8 billion dollars. The carbapenem antibiotics is 1 billion annually. Now carbapenem in the drug market share is rising, the demand for carbapenem in market had increased by 50% last year. Thus carbapenem drug has been the hot development of antibiotics . Market prospects However, the potential exists for some metallob lactamases that can destroy carbapenem pounds to be more disseminated. prudent prescibing practice should screen multidrugresistant isolates for this mechanism. Only with this effort will doripenem be able to maintain its wide spectrum of activity and potential clinical utility. Market prospects References 4. Shihomi Sakyo, Haruyoshi Tomita, Koichi Tanimoto, Shuhei Fujimoto, Yasuyoshi Ike. Potency of Carbapenems for the Prevention of CarbapenemResistant Mutants of Pseudomonas aeruginosa. J. Antibiot. 59(4): 220–228, 2023 5. Masahito Horiuchi, Megumi Kimura, Miwa Tokumura, Nobuyoshi Hasebe, Tohko Arai, Kohji Abe Absence of convulsive liability of doripenem, a new carbapenem antibiotic, in parison with _lactam antibiotics [1]Ronald N. Jones,1,2* Holly K. Huynh,1 and Douglas J. Biedenbach1 Activities of Doripenem (S4661) against DrugResistant Clinical Pathogens [2] Shazad Mushtaq,1 Yigong Ge,2 and David M. Livermore1 Comparative Activities of Doripenem versus Isolates, Mutants, and Transconjugants of Enterobacteriaceae and Aciobacter spp. with Characterized _Lactamases [3] David Leif Anderson DORIPENEM Medical Information Department, Prous Science, Barcelona, Spain [4] Ronald N. Jones1,2*, Holly K. Huynh1, Douglas J. Biedenbach1, Thomas R. Fritsche1 and Helio S. Sader1 Doripenem (S4661), a novel carbapenem: parative activity against contemporary pathogens including bactericidal action and preliminary in vitro methods evaluations [5] THYE DA, KILFOIL T, LEIGHTON A, WIKLER M. Doripenem: a Phase 1 Study to Evaluate Safety, Tolerability and Pharmacokiics in a Western Healthy Volunteer Population. [6] Yoshitsugu Nakajima, Minoru Mizobuchi, Masahiro Nakamura, Hidetoshi Takagi, Haruhisa Inagaki, Goro Kominami, Masahiro Koike, and Toshiro Yamaguchi MECHANISM OF THE DRUG INTERACTION BETWEEN VALPROIC ACID AND CARBAPENEM ANTIBIOTICS IN MONKEYS AND RATS References 朱雪焱 袁哲東 多尼培南的合成 中國醫(yī)藥工業(yè)雜志 2023, Vol37, p361363 黃娟 吳勇 王光明 Doripenem 關(guān)鍵中間體的合成工藝研究 中國抗生素雜志 2023 年 12月第 31卷 第 12期 p746748 演講完畢，謝謝觀看！
環(huán)評公示相關(guān)推薦
鄂ICP備17016276號-1