妊娠期肝內(nèi)膽汁淤積癥患者膽酸水平變化對(duì)胎兒心臟的影響-資料下載頁
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【正文】 生兒臍動(dòng)脈血TBA、cTnI濃度均呈正相關(guān)，這與動(dòng)物實(shí)驗(yàn)以及離體細(xì)胞培養(yǎng)結(jié)果一致。說明膽汁酸的毒性作用導(dǎo)致胎兒心肌損傷、心功能異常，心肌損傷越嚴(yán)重對(duì)心臟功能的影響越大。胎兒左室心臟Tei指數(shù)能夠反映出左心室功能異常及心肌損傷的程度，可作為臨床監(jiān)測(cè)胎兒心臟功能及心肌損傷的指標(biāo)。參考文獻(xiàn)[1] Wang XD,Peng B,Yao Q,Zhang L,et outes of intrahepatic cholestasis of pregnancy: analysis of 1210 Yi Xue Za Zhi,2006,86:446449.[2]王春芳，王宏，李笑天．妊娠肝內(nèi)膽汁淤積癥導(dǎo)致胎兒并發(fā)癥的病理生理學(xué)研究進(jìn)展．中華婦產(chǎn)科雜志，2005，40:355357．[3]樂杰．婦產(chǎn)科學(xué)．7版．北京：人民衛(wèi)生出版社，2007:101103[4]譚宜,周啟昌,王小艷. Tei指數(shù)在胎兒心功能評(píng)價(jià)中的應(yīng)用，中國醫(yī)學(xué)影像技術(shù)，2005,21:592－594.[5]邵 勇，姚珍薇． 探索產(chǎn)科領(lǐng)域的百慕大之謎．醫(yī)學(xué)與哲學(xué)，2005，26:3942[6]丁依玲,2005,8:168170.[7]Ostrow JD. In vitro studies of bile salt toxicity . Hepatology, 1994, 19: 15381539.[8]Jaffe AS, Ravkilde R. It’s time for change to a troponin standard . Circulation, 2000, 102:12161220.[9]Williamson C, Gorelik J,Eaton BM,et bile acid taurochlate impairs rat cardiomyocyte function:a proposed mechanism for intrauterine fetal death in obstetric Sci(Lond),2001,100: 363369.[10]Groreli K J,Shevchuk A I，Diakono VI, et al. Dexamethasone and ursodeoxy cholic acid protect against the arrhyth mogenic effect of taurocholate in an vitro study of rat Cardiomyocytes [J].Br Jobs Gyn,2003,110:467474.[11]Gorelik J, Shevchuk A, Swiet M, et al. Comparison of the arrhythmogenic effects of tauro and glycoconjugates of cholicacid in an in vitro study of rat cardiomyocytes [J] . BJOG, 2004 ,111(8):867870. [12]Green J,Beyar R, sideman S, et Jaunaiced heart:Apossible explanation for postoperative shock in obstructive Janndive . Surgery, 2003, 100: 1420.
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