91)周佳-敗血癥影響藥動學行為的病理生理機制及其對抗生素tdm監(jiān)測doc-資料下載頁
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【正文】 early in sepsis despite increased hepatic blood flow and cardiac output. Arch Surg 1991。 126: 219224[5] Chrusch C, Bands C, Bose D, et hepatic extraction and increased splanchnic production contribute to lactic acidosis in canine J Respir Crit Care Med. 2000 。 161(2 Pt 1):51726.[6]Mann HJ, Townsend RJ, Fuhs DW, et al. Decreased hepatic clearance of clindamycin in critically ill patients with sepsis. Clin Pharm 1987。 6: 154159[7] Jones EM, McMullin CM, Hedges AJ, et al. The pharmacokinetics of intravenous ciprofloxacin 400mg 12 hourly in patients with severe sepsis: the effect of renal function and intraabdominal disease. J Antimicrob Chemother 1997。 40:121124[8] Gous A, Lipman J, Scribante J, et shifts have no influence on ciprofloxacin pharmacokinetics in intensive care patients with intraabdominal J Antimicrob Agents. 2005。26(1):505.[9]Hickling KG, Begg EJ, Perry RE, et al. Serum aminoglycoside clearance is predicted as poorly by renal aminoglycoside clearance as by creatinine clearance in critically ill patients. Crit Care Med 1991。 19: 10411047[10] Tang GJ, Tang JJ, Lin BS, et affecting gentamicin pharmacokinetics in septic Anaesthesiol Scand. 1999 Aug。43(7):72630.[11]Jason A. Roberts and Jeffrey Lipman，Antibacterial Dosing in Intensive CarePharmacokinetics, Degree of Disease and Pharmacodynamics of Sepsis Clin Pharmacokinet 2006。 45: 755773[12]Craig WA. Basic pharmacodynamics of antibacterials with clinical applications to the use of blactams, glycopeptides, andlinezolid. Infect Dis Clin North Am 2003。 17: 479501[13] Alarabi AA, Cars O, Danielson BG, et al. Pharmacokinetics of intravenous imipenem/cilastatin during intermittent haemofiltration. J Antimicrob Chemother 1990。 26: 9198[14] Kihara M, Ikeda Y, Shibata K, et al. Pharmacokinetic profiles of intravenous imipenem/cilastatin during slow hemodialysis in critically ill patients. Clin Nephrol 1994。 42: 193197[15] Mouton JW, van den Anker JN. Meropenem clinical pharmacokinetics. Clin Pharmacokinet 1995。 28: 275286[作者簡介] 周佳，女，藥師，上海長海醫(yī)院臨床藥師，從事臨床藥學實踐和臨床藥理學研究。8 / 8
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