醫(yī)藥衛(wèi)生]菌群與腸道疾病-資料下載頁
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【正文】 ients ? All given steroids – 59 given mesalamine (Pentasa, Asacol) – 57 given a probiotic ? Remission rates similar (75% vs. 68%) ? Relapse rates similar (73% vs. 67%) ? Length of remission similar (206 days vs. 221 days) Rembacken et al Lancet, 1999 益生菌治療 UC 克羅恩病的維持治療 32例臨床緩解的 CD 美沙拉嗪 美沙拉嗪 1克 tid 1克 Bid+布拉地酵母菌 (saccharomyces boulardii) 療程 6月 6月 復(fù)發(fā) % % (CDAI) Guslandi M等 DDS 2022 用益生菌處理小鼠的結(jié)腸內(nèi) 炎性細(xì)胞數(shù)量減少 Lactobacilli and Bifidobacteria Why They Are Safe ? Many exposures in pediatrics – Fermented foods – Probiotics – The host’s own microflora ? Oral cavity ? Ileum and colon ? Vagina ? Cases of infection extremely rare Account for % to % of infective endocarditis and bacteremia Less than 1 case per million people ? Review of 143 human clinical trials from 19611988 – Over 7500 subjects – No reported adverse events Lactobacilli and Bifidobacteria Why They Are Safe Lactobacilli and Bifidobacteria Why They Are Safe ? Increasing probiotic consumption has not led to increased opportunistic infections – National Public Health InstituteFinland 19951999 ? Increasing cases of bacteremia (all types) ? Increasing use of probiotics ? Constant level of Lactobacillus bacteremia
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