【正文】
% (CDAI) Guslandi M等 DDS 2022 用益生菌處理小鼠的結(jié)腸內(nèi) 炎性細(xì)胞數(shù)量減少 Lactobacilli and Bifidobacteria Why They Are Safe ? Many exposures in pediatrics – Fermented foods – Probiotics – The host’s own microflora ? Oral cavity ? Ileum and colon ? Vagina ? Cases of infection extremely rare Account for % to % of infective endocarditis and bacteremia Less than 1 case per million people ? Review of 143 human clinical trials from 19611988 – Over 7500 subjects – No reported adverse events Lactobacilli and Bifidobacteria Why They Are Safe Lactobacilli and Bifidobacteria Why They Are Safe ? Increasing probiotic consumption has not led to increased opportunistic infections – National Public Health InstituteFinland 19951999 ? Increasing cases of bacteremia (all types) ? Increasing use of probiotics ? Constant level of Lactobacillus bacteremia 。 ** ? 擬桿菌 177。腸道菌群與腸道疾病 天津市南開醫(yī)院 曹澤偉 2022- 12- 12 人體微生態(tài)系統(tǒng) ? 出生后 0- 12個月形成,終生維持穩(wěn)定狀態(tài) ? 人體正常菌群大約 400-500菌種 數(shù)量達(dá) 100萬億個(人體體細(xì)胞只有 10萬億個) ? 總重量 1- 2kg,約 75%以上的糞便成分是細(xì)菌及其副產(chǎn)物 ? 如果將一個人的腸內(nèi)細(xì)菌排成一列,其長度約可繞行地球 2周多 腸黏膜屏障 正常菌叢(益生菌) 與腸道致病菌競爭機(jī)制 ? 占領(lǐng)空間,競爭必需營養(yǎng)與上皮附著點 ? 制造抗微生物成份,揮發(fā)性脂肪酸,修飾膽酸,不利致病菌生長環(huán)境 ? 誘導(dǎo)免疫細(xì)胞匯集,激活適當(dāng)?shù)拿庖吲c炎癥反應(yīng) 單位 消化鏈球菌 ,