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【導(dǎo)讀】詢問(wèn)與臨床決策或行動(dòng)有關(guān)的特殊知識(shí)。包含四個(gè)必要成分:. 比較，如果有關(guān)的話。臨床結(jié)果，如果有關(guān)的話應(yīng)包括時(shí)間。治療，但是要用多少劑量?1支,2支,5支……b具有嚴(yán)格的信賴區(qū)間的個(gè)別RCT研究。2a將同質(zhì)性的世代研究以系統(tǒng)性評(píng)論的結(jié)果。b個(gè)別世代研究或是質(zhì)量較不足的RCT研究。c以多數(shù)結(jié)果為基礎(chǔ)的研究，及生態(tài)學(xué)的研究("Outes"research;3a將同質(zhì)的個(gè)案對(duì)照研究以系統(tǒng)性評(píng)論後的結(jié)果。4病例統(tǒng)計(jì)報(bào)告，以及質(zhì)量較不足的個(gè)案對(duì)照研究。
【正文】 ? BACKGROUND AND AIM: Protonpump inhibitor (PPI) therapy for bleeding ulcers is more efficacious in Asian patients than in nonAsian patients. The aim of this study was to evaluate the efficacy of various doses of pantoprazole on intragastric acidity in Korean patients. METHODS: A prospective randomized study was conducted in 52 patients either with bleeding peptic ulcers after successful endotherapy or who received endoscopic mucosal resection for gastric neoplasms. Patients were randomized into two doses of intravenous pantoprazole: 40 mg . and 40 mg . We pared these results with our preliminary study utilizing highdose pantoprazole (80 mg + 8 mg/h). The potential contribution of CYP2C19 geic polymorphisms and the presence of Helicobacter pylori were also assessed. RESULTS: Pantoprazole 40 mg . and highdose pantoprazole demonstrated better inhibition of intragastric acid than pantoprazole . (P ). The pantoprazole 40 mg . group exhibited significant variations in acid inhibition correlating with CYP2C19 genotype. Median 24 h pH values did not differ significantly between the pantoprazole . and highdose pantoprazole groups, regardless of H. pylori infection status. A median intragastric pH was observed in only three of 28 patients in the 40 mg . group。 these three patients were extensive metabolizers. ? CONCLUSION: A 40 mg . dose of pantoprazole is sufficient to maintain pH in Korean patients, except for patients with extensive metabolizing CYP2C19 genotypes.
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