使用gradepro評價證據(jù)質(zhì)量(編輯修改稿)
2025-03-12 00:54 本頁面
【文章內(nèi)容簡介】 owngrade the evidence for this oute by 1 level187。 ? If you have very serious doubts about directness choose very serious 171。this will downgrade the evidence for this oute by 2 levels187。 精確度不夠（ Imprecision ） ? 當(dāng)研究納入的患者和觀察事件相對較少而致可信區(qū)間較寬時，指南小組將降低該研究的證據(jù)質(zhì)量。 ? A threshold ruleofthumb value — Total number of events is less than 300（ dichotomous） — Total population size is less than 400（ continuous） To rate imprecision: ? If you think the results were precise choose no ? If there was serious imprecision choose serious 171。this will downgrade the quality of evidence for this oute by 1 level187。 ? If there was very serious imprecision choose very serious 171。this will downgrade the quality of evidence for this oute by 2 levels187。 發(fā)表偏倚（ Publication bias ） ? Publication bias arises when investigators fail to report studies they have undertaken (typically those that show no effect). Methods to detect the possibility of publication bias in systematic reviews exist, although authors of the reviews and guideline panels must often guess about the likelihood of publication bias. A prototypical situation that should elicit suspicion of publication bias occurs when published evidence is limited to a small number of trials, all of which are showing benefits of the studied intervention. ? 若研究者未能發(fā)表研究（通常是陰性結(jié)果的研究）時，證據(jù)質(zhì)量亦會減弱。典型情況是當(dāng)公開的證據(jù)僅局限于少數(shù)試驗而這些試驗全部由企業(yè)贊助，此時不得不質(zhì)疑存在發(fā)表偏倚。 Funnel Plot To rate probability of the publication bias: ? If you think there is no evidence of publication bias choose unlikely ? If there is high probability of publication bias choose likely 171。this will downgrade the quality of evidence
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