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(TLoop) sequence of MAP kinases First Military Medical University Construction of p38 loop12 to ERK like structure p38 ...DFGLARHTDDEMTGYVATRWYRAPE... p38(E) ...DFGLARHTDDEMTEYVATRWYRAPE... p38(6+) ...DFGLARHTDDEHDHTGFMTGYVATRWYRAPE... p38(6+E) ...DFGLARHTDDEHDHTGFMTEYVATRWYRAPE... p38(VAP) ...DFGLARVADPEMTGYVATRWYRAPE... p38(DL) ...DFGLARHTDDDLTGYVATRWYRAPE... p38(VAPD6+LE) ...DFGLARVADPDHDHTGFLTEYVATRWYRAPE... ERK2 ...DFGLARVADPDHDHTGFLTEYVATRWYRAPE... First Military Medical University MAPK MKK Substrates Loop12 is a key structure to determine the selection of substrate ? ? (...TXY...) First Military Medical University 病毒技術(shù)對于揭示細(xì)胞信號通路的作用 ?腺病毒 ?逆轉(zhuǎn)錄病毒 First Military Medical University First Military Medical University First Military Medical University 細(xì)胞信號分子特異性抑制劑的應(yīng)用 First Military Medical University 幾種 MAPK通路抑制劑的化學(xué)結(jié)構(gòu)示意圖 : O NH2 OCH3 O PD98059 HN N S O F CH3 N OH N F N H N SB202190 SB203580 CH=CH? CH=CH? OH OCH3 OH OCH3 O O Curcumin First Military Medical University Effects of SB203580 and PD98059 on endogenous PRAK activity HSP27 TNF? + + + Arsenite + + + PMA + + + SB203580 _ + + + PD98059 + + + First Military Medical University 細(xì)胞信號分子的熒光標(biāo)記 First Military Medical University LPS EGF Control First Military Medical University p38 p38? p38? p38? First Military Medical University