藥理學ppt課件南開大學第三章藥物代謝動力學(編輯修改稿)
2025-04-18 03:33 本頁面
【文章內(nèi)容簡介】 ? Feature ? Result ? Significance ② Barrier ? Bloodbrain barrier (BBB) ? Placenta barrier ? Bloodeye barrier Metabolism 4. Enzyme 5. Enzyme induction ① PhaseⅠ oxidations, reductions, hydrolysis； ② Phase Ⅱ conjugations Special enzyme Nonspecial enzyme (hepatic microsomal mixed function oxidase system) ?Cytochrome P450 ?NADPH ?Flavoprotein ?Inducers ?Inhibitors Activity ↑ or ↓ Toxicity ↑ or ↓ Excretion ? Concept ? Route ? Kidney ? Filtration ? Excretion ? Bile Hepatoenteral circulation ③ Milk ④ Saliva ⑤ Skin ⑥ Lungs Timeconcentration curve time Metabolism and elimination phase Cmax Latent period Continuance period Remnant period MTC MEC Tmax Drug concentration(mg/L) Absorption and distribution phase Timeconcentration relationship Cmax Cmax Tpeak Elimination kiics nkCdtdC??Elimination kiics 1. Zeroorder kiics ① Concept ②
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