營養(yǎng)與ob、as、高血壓(編輯修改稿)
2025-04-14 10:09 本頁面
【文章內容簡介】 50 125 120 115 110 110 40 110 110 105 100 100 藥物 ?輕瀉 ?全營養(yǎng)素 ?興奮中樞神經 ?阻礙脂肪吸收 ?促進能量消耗 ?基因療法 非藥物 ?針灸（耳針） ?拔火罐 ?香熏 ?按摩 ?推拿 ?氣功 疾病死亡率排行 1957 ?肺炎 ?急性傳染病 ?肺結核 1980sPresent ?腦血管病 ?心血管病 ?惡性腫瘤 ?糖尿病 發(fā)病率 ?高血壓 % ?糖尿病 % ?高脂血癥 % (南京 :中國公共衛(wèi)生 2022,20:12341236) ?高血壓 % ?糖尿病 % ?高脂血癥 % (福州 :中國公共衛(wèi)生 2022,20:12421243) 心腦血管疾病 ?高血壓 （ Hypertension） ?動脈粥樣硬化 （ Atherosclerosis, AS） 心臟冠狀動脈 —冠心病 腦動脈 ——腦血管功能不全或中風（腦卒中） Nonmunicable Disease Model Environment Air Pollution Behavioral choices Your geic endowment 心血管疾病的危險因素 ?飲食：不平衡 、 高脂肪 、 高鹽 ?肥胖 ?精神壓力 ?吸煙 、酗酒 ?少運動 ?遺傳 AS的發(fā)生發(fā)展過程 ?損傷因子引起內皮細胞功能紊亂，炎性細胞遷移并積聚內膜下 ?單核細胞攝取脂質并轉化成巨噬泡沫細胞，脂質條紋形成 ?血管平滑肌細胞增殖， AS斑塊形成（纖維帽） ?斑塊破裂 Endothelial Dysfunction in Atherosclerosis. The earliest changes that precede the formation of lesions of atherosclerosis take place in the endothelium. From: Ross, N Eng J Med 1999,340(2) 11526 FattyStreak Formation in Atherosclerosis. Fatty streaks initially consist of lipidladen monocytes and macrophages (foam cells) together with T lymphocytes. Later they are joined by various numbers of smoothmuscle cells. Formation of an Advanced, Complicated Lesion of Atherosclerosis. As fatty streaks progress to intermediate and advanced lesions, they tend to form a fibrous cap that walls off the lesion from the lumen. Unstable Fibrous Plaques in Atherosclerosis. Rupture of the fibrous cap or ulceration of the fibrous plaque can rapidly lead to thrombosis and usually occurs at sites of thinning of the fibrous cap that covers the advanced lesion. Participation of inflammation in all stages of atherosclerosis. A, Leukocyte recruitment to the nascent atherosclerotic lesion. B, T lymphocytes join macrophages in the intima during lesion evolution. C, Ultimately, inflammatory mediators can inhibit collagen synthesis and evoke the expression of collagenases by foam cells within the intimal lesion. From: Libby: Circulation, Volume 105(9).March 5, 脂類與 AS ? 總脂肪攝入量 ? 飽和脂肪攝入量 —CHO升高， TG ? 單不飽和脂肪酸 —降低 CHO、 LDL ? N6多不飽和脂肪酸 —降低 LDL、 HDL
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