脂質(zhì)體運用于胰島素口服給藥治療糖尿病的可能性外文翻譯(編輯修改稿)
2025-06-25 18:45 本頁面
【文章內(nèi)容簡介】 intraperitoneal injection of alloxan hydrate,in a dose of 150 mg per kg of body was administered in liposomes per os to 38 rats with severe diabetes was collected for the investigation before the animals were concentration of immunoreactive insulin and the binding peptide (Cpeptide) was determined in the blood serum (after sacrifice of the animals) by a radioimmune method. In rats with severe diabetes mellltus (see Table I), against a background of serious general condition (pronounced listlessness, thirst~ anorexia, dryness Of the mucosa and fur),substantial hyperglycemia and pronounced hypolnsullnemla were noted. The level of the Cpeptide in the blood serum was significantly lower than in healthy animals. Without treatment such animals died within the first week after the administration of alloxan peroral administration :of insulin in llposomes, within only i h a tendency was noted for a decrease in the glucose content in the blood, intensified by the 4th hour after administration of the preparation~ In certain animals signs of clinical hypoglycemia were even observed: excitation, agressiveness, a rapid drop in the blood sugar level, and convulsions in a number of cases. In healthy rats we did not detect such reactions. The conditions of the rats with hypoglycemia was improved after they were given a glucose solution. The hypoglycemic effect of simple insulin in liposomes was prolonged. After 24 h the blood sugar level was lower in 90%of the animals than before the administration of the preparation. The condition of most of the animals was significantly improved。 they became more active .It should be noted that in rats with alloxan diabetes mellitus, against the background of admininstration of insulin in liposomes, high levels of insulin in the blood serum were detected,evidently as a result of the release of insulin from the llposomes. This is demonstrated,on the one hand, by the absence of an increase in insulinemia in rats of the control groups,and on the other hand, by detection of low levels of blood serum Cpeptide, which is formed from proinsulin in equimolar amounts with insulin. The condition of the animals was improved against a background of administration of insulin in liposomes, and the lifetime was increased(in each lot the animals treated with the liposomal form of insulin survived significantly better than the controls). The introduction of pure liposomes (without insulin) or a mixture of insulin with liposomes without enclosure of the hormone inside did not give such a pronounced effect, although it did exhibit a small hypoglycemic action, which we are inclined to explain by an increase in the sensitivity of the peripheral tissues, in particular, the liver, to the action of circulating endogenous insulin, present in the organism in small amounts, in connection with the incorporation of the liposomal phospholipids into
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