有機(jī)合成路線設(shè)計(jì)原理-全文預(yù)覽
【正文】 ting selected carboncarbon bonds. These disconnections rest on transforms, which are the reverse of plausible synthetic constructions. Each simpler structure, so generated, bees the starting point for further disconnections, leading to a branched set of interrelated intermediates. A retrosynthetic transform is depicted by the = symbol, as shown in next slide. Once a plete analysis has been conducted, the desired synthesis may be carried out by application of the reactions underlying the transforms. 2020/9/15 4 O HP hP hCP hO HCP h+OH P hC M g B rP h合 成 子 等 價(jià) 試 劑合 理 的 切 割Synthon Equivalent Disconnection rest on transforms 2020/9/15 5 O HP hP hC+P hO HCP h不 合 理 的 切 割2020/9/15 6 C+ROCR C lOCR O ROR+ R XO HC+RR HOOCRS SR L iR R M g XCR CN a+R C M g XRSynthon Equivalent Polar Inversion 極性反轉(zhuǎn) 2020/9/15 7 OOC+B rSSL iSSH+C H OOSS N B Sa q . a c e t o n ePolar Inversion 2020/9/15 8 C H OC H O1 . O 32 . Z n / A c O HSymbol 2020/9/15 9 N H 2 C NH 2P d / CB rN a C NO H O HFunctional Group transforms 2020/9/15 10 O O HP C C 1 . B 2 H 62 . H 2 O 2 N a O H2020/9/15 11 2. Disconnection on TMs without FG —— adding FG + B rN a CHB rH H +TM： targeted molecule 目標(biāo)分子 2020/9/15 12 OC lO+A l C l 32020/9/15 13 B r B rB rB r B rB rN H 21 . N a N O 2 , H C l2 . E t O HN H 2N H 2N H 2C N+C N2020/9/15 14 3. Discon
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