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chapter38macrolides,lincomycinsandpolymycins-文庫(kù)吧資料

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【正文】 onella(軍團(tuán)菌) ,bacillus pertussis(百日咳 ), brucella(布氏 ) , meningococci, diplococcus gonorrhoeae etc ? Others: mycoplasma(支原體 ), chlamydia trachomatis(沙眼衣原體 ), rickettsia(立克次體 ), spirochete ,anaerobes etc. Erythromycin ?Clinical uses ? As penicillin substitute in penicillinallergic or resistant patients with infections caused by staphylococci, streptococci and pneumococci ? Pertussis, diphtheriae ? Legionella and mycoplasma pneumonia ? infection Erythromycin ?Adverse reactions ? Gastrointestinal effects ? Liver toxicity ? Cardiotoxicity Erythromycin ? Erythromycin lactobionate(乳糖酸紅霉素) ? erythromycin estolate(無(wú)味紅霉素 ) ? erythromycin stearate(硬脂酸紅霉素) ? erythromycin ethylsuccinate(琥乙紅霉素, 利君沙 ) New macrolides antibiotics ? Advantage : ? Broader spectrum, higher activity ? Orally effective ? High blood concentration ? Longer t 1/2 ? Less toxicity ? Mainly used in
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