【導(dǎo)讀】用,青霉素的發(fā)酵對人們生活中治療疾病有很好的療效。藝設(shè)計(jì)與研究對青霉素工廠的發(fā)展有極其重要的作用?；S車間的消毒。近年來國內(nèi)外市場對青霉素的需求呈攀升趨勢，

　　

【正文】 ）公稱 500m3 的發(fā)酵罐： a．幾何大小 500m3 的發(fā)酵罐徑高比為 3，即 H=3D， V=（ πD2/4）3D=100 ，得到直徑 D=，高 HL=。 b．傳熱面積 內(nèi)蛇罐 36（ 6 組） ， F=562m3 c．?dāng)嚢杵? 攪拌器直徑： Dj=1/2D= 擋板寬度 ： B== 攪拌葉間距： S= =， 攪拌葉與罐底距離 C= Dj =。 C+3S=+3 =H L , 則取四層攪拌器。 2）公稱為 100m3 的發(fā)酵罐 a．幾何大小 100m3 的發(fā)酵罐徑高比為 ，即 H=， V=（ πD2/4）=100 ，得到直徑 D=，高 HL=。 b．傳熱面積 內(nèi)蛇罐 36（ 6 組） ， F=114m3 c．?dāng)嚢杵? 攪拌器直徑： Dj=1/3D= 擋板寬度 ： B== 攪拌葉間距： S=2Dj =， 攪拌葉與罐底距離 C= Dj =。 C+3S=+3 =H L , 則取四層攪拌器。 3) 公稱為 20 m3 的發(fā)酵罐 a．幾何大小 20 發(fā)酵罐的徑高比為 ，即即 H=， V=（ πD2/4）=100 ，得到直徑 D=，高 HL=。 b．傳熱面積 外盤管 40 ， F=40m3 c．?dāng)嚢杵? 攪拌器直徑： Dj=1/3D= 擋板寬度 ： B== 攪拌葉間距： S=2Dj =， 攪拌葉與罐底距離 C= Dj =。 C+3S=+2=H L , 則取三層攪拌器。 發(fā)酵罐圖如下： 年產(chǎn) 1 萬噸青霉素原料藥工廠發(fā)酵車間的設(shè)計(jì) 22 、 圖 13 發(fā)酵罐簡圖 1罐體； 6無菌空氣 所選擇的主要設(shè)備如下表： 表 5 所選主要設(shè)備 設(shè)備名稱 規(guī)格型號 數(shù)量（個(gè)） 生 產(chǎn)廠家 二級發(fā)酵罐 500 m3 8 無錫市雪浪發(fā)酵工程設(shè)備廠 一級發(fā)酵罐 100m3 6 無錫市雪浪發(fā)酵工程設(shè)備廠 種子罐 20m3 3 無錫市雪浪發(fā)酵工程設(shè)備廠 6 車間總體布局 車間組成 通過對發(fā)酵車間設(shè)備構(gòu)成以及工藝路線的研究，可以判斷發(fā)酵車間的主要有發(fā)酵罐間、 CIP 間、空氣凈化間、無菌水供應(yīng)間、培養(yǎng)基原料處理間和配料間補(bǔ)料間等。 車間布局原則 （ 1）最大限度的滿足工藝生產(chǎn)包括設(shè)備維修的要求； （ 2）有效的利用車間建筑面積（包括空間）和土地； （ 3）要為車間的技術(shù)經(jīng) 濟(jì)指標(biāo)、先進(jìn)合理以及節(jié)能等要求創(chuàng)造條件； （ 4）考慮其他專業(yè)對本車間布局的要求； （ 5）要考慮車間的發(fā)展和廠房的擴(kuò)建； （ 6）車間中所采用的勞動保護(hù)、防腐、防火、防毒、防爆以及安全衛(wèi)生等措施是否符合要求； （ 7）本車間與其他車間在總平面圖上位置合理，力求使他們之間輸送 管線最短，聯(lián)系最方便； （ 8）考慮廠房地區(qū)的氣象、地質(zhì)、水文等條件； （ 9）人流、物流不能交錯(cuò)。 車間布局圖 車間布局圖是根據(jù)以上工藝流程和設(shè)備選型，結(jié)合當(dāng)?shù)氐臍夂驐l件和廠址選擇地點(diǎn)所設(shè)計(jì)的車間各部分大小和配備設(shè)施而設(shè)計(jì)的工 程圖。由物料衡算和設(shè)備選型，此設(shè)計(jì)所布局的圖如附表。 年產(chǎn) 1 萬噸青霉素原料藥工廠發(fā)酵車間的設(shè)計(jì) 24 致 謝 本論文是在導(dǎo)師的悉心指導(dǎo)下完成的。很長一段時(shí)間，恩師在我的學(xué)士學(xué)位課程學(xué)習(xí)，設(shè)計(jì)研究工作、教學(xué)活動、學(xué)術(shù)交流、論文撰寫和工作生活等方面都給予了極大的關(guān)懷和支持，并為我提供了良好的學(xué)習(xí)研究環(huán)境。導(dǎo)師的嚴(yán)謹(jǐn)治學(xué)、孜孜不倦、持之以恒的師表風(fēng)范是我終身學(xué)習(xí)的楷模，在此向恩師表示誠摯的感謝和崇高的敬意！ 感謝所有關(guān)心、幫助和支持我的老師、同學(xué)們！ 參 考 文 獻(xiàn) 1 唐燕輝 .藥物制劑生產(chǎn)設(shè)備及車間工藝設(shè)計(jì) .北京 :化學(xué)工業(yè)出版社 .2021 2 段開紅 .生物工程設(shè)備 .北京 :科學(xué)出版社 .2021 3 元英進(jìn) ,趙廣榮 ,孫鐵民 .北京 :化學(xué)工業(yè)出版社 .2021 4 夏煥章 ,熊宗貴 .北京 :高等教育出版社 .2021:259— 306 5 余龍江 .生物制藥工廠工藝設(shè)計(jì) .化學(xué)工業(yè)出版社 . 6 蔡功祿。發(fā)酵工廠設(shè)計(jì)概論 .中國輕工業(yè)出版社 .2021 7 張洪斌，杜志剛 .制藥工程課程設(shè)計(jì) .北京 .化學(xué)工業(yè)出版社 .2021 8 李鈞 .藥品 GMP 文件化教程 .中國醫(yī)藥科技出版社 .2021 9 姚日生 ,梁世中 .制藥工程原理與設(shè)備。高等教育 出版社 .合肥。 g an employment tribunal claim Employme nt tribunals sort out disagreements between employers and employee s. You may need to make a claim to an employment tribunal if: ? you don39。t agree with the disciplinar y action your employer has taken again st you ? your employer dismisse s you and you think that you have been dismissed unfairly. For more information about dismissal and unfair dismissal, see Dismissal. You can make a claim to an e mployme nt tr ibunal, even if you haven39。 t appe ale d against the disciplinar y action your e mployer has taken against you. However, if you win your case, the tribunal may reduce any pensation awarded to you as a result of your failure to appeal. Re me mber that in most cases you must make an application to an e mployme nt tr ib unal within three months of the date whe n the event you are plaining about happened. If your application is re ceived after this time limit, the tr ibunal will not usually accept it. If you are worried about how the time limits apply to you, take advice f rom one of the anisations listed under Further help. Employme nt tribunals are less formal than some other courts, but it is still a legal process and you will need to give evidence under an oath or affirmation. Most people find making a claim to an employment tribunal challenging. If you are thinking about making a claim to an e mployment tr ibunal, you should get he lp straight away from one of the anisations listed under Further help. If you are be ing repre sente d by a solicitor at the tribunal, the y ma y ask you to sign an agree ment where you pay the ir fee out of your pensation if you win the case . This is known as a damagesbased agreement. In England and Wales, your solicitor can39。t charge you more than 35% of your pensation if you win the case. If you are thinking about signing up for a damagesbase d agreement, you should make sure you39。re cle ar about the ter ms of the agree me nt. It might be be st to ge t advice from an experienced adviser, for example, at a Citizens Advice Bureau. To find your nearest CAB, including those that give advice by e mail, click on nearest CAB. For more information about making a claim to an employment tribunal, see Employment tribunals. The (lack of) air up there 年產(chǎn) 1 萬噸青霉素原料藥工廠發(fā)酵車間的設(shè)計(jì) 26 Watch mCayman Islandsbased Webb, the head of Fifa39。s antiracism taskforce, is in London for the Football Association39。s 150th anniversary celebrations and will attend City39。s Premier League match at Chelsea on Sunday. I am going to be at the match tomorrow and I have asked to meet Yaya Toure, he told BBC Sport. For me it39。s about how he felt and I would like to speak to him first to find out what his experience was. Uefa has opened disciplinary proceedings against CSKA for the racist behaviour of their fans during City39。s 21 win. Michel Platini, president of European football39。s governing body, has also ordered an immediate investigation into the referee39。s actions. CSKA said they were surprised and disappointed by Toure39。s plaint. In a statement the Russian side added: We found no racist insults from fans of CSKA. Age has reached the end of the beginning of a word. May be guilty in his seems to passing a lot of different life became the appearance of the same day。 May be back in the past, to oneself the paranoid weird belief disillusionment, these days, my mind has been very messy, in my mind constantly. Always feel oneself should go to do something, or write something. Twent y years of life trajectory deeply shallow, suddenly feel something, do it. 一字開頭的年齡已經(jīng)到了尾聲?；蛟S是愧疚于自己似乎把轉(zhuǎn)瞬即逝的很