【正文】
DNA methylation, chromatin, and posttranslational modification of proteins such as histones. Arrows indicate possible functional interactions between them. DNA hypermethylation, histone hypoacetylation and inactive chromatin repress transcription. In contrast, a transcriptionally active condition may encourage DNA hypomethylation, histone hyperacetylation and active chromatin. Also, a particular chromatin structure may be required for establishing DNA methylation . 研究還表明,組蛋白甲基化可以與基因抑制有關(guān),也可以與基因的激活相關(guān),這往往取決於被修飾的賴(lài)氨酸處?kù)妒颤N位置。 例如,上述的 H3 Lys9甲基化最終導(dǎo)致了基因的沉默;然而,位於 H3 Lys4的甲基化則與基因的活化相關(guān)聯(lián)。