缺氧導(dǎo)致的病理性血管再生與腫瘤遷移-資料下載頁(yè)
2025-05-26 18:09本頁(yè)面
【正文】 iogenesis and metastasis ?How does VEGFinduced angiogenesis facilitate tumor cell invasion and metastasis? ?One possibility is that VEGF induces disanized, leaky and tortuous vasculatures, which are susceptible for malignant cell invasion. In support of this hypothesis, increases of vascular density and tortuosity have been observed in our zebrafish model. ?The other possible mechanism is that outgrowth of blood vessels in tumors promotes intimate interactions between malignant and endothelial cells and the latter provides niches for tumor cell invasion and metastasis. ?Additionally, perfusion of VEGFinduced vessels could act as a chemoattractant for tumor cell migration and eventually lead to tumor cell invasion along the vascular system. ? Inhibition of tumor angiogenesis might prevent metastasis. Inversely, recent reports show that antiangiogenic drugs for treatment of established animal tumors lead to invasion and metastasis. ?The difference between these findings and our data could be due to the sizes of primary tumors. ?In an established tumor, antiVEGF drugs could generate tissue hypoxia, leading to an invasive and metastatic phenotype. ?In zebrafish tumor model, primary tumors remain in situ as tiny nodules and antiangiogenic drugs would not result in significant hypoxia as in a wellestablished tumor. ?Thus, tumor sizes might be a key determinant for antiangiogenic drugproduced therapeutic benefits or tumor cell invasion and metastasis. ?A substantial number of patients are diagnosed for malignant diseases owing to metastasis as the first sign of cancer. ?Primary tumors remain undetectable using conventional techniques, suggesting that dissemination of tumor cells occurs at the very early stage. ?Thus, our results shed light on early metastatic processes by visualizing single cell invasion and metastasis in the living body without invasive procedures.
環(huán)評(píng)公示相關(guān)推薦
鄂ICP備17016276號(hào)-1