分子生物學(xué)緒論(1)-資料下載頁(yè)
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【正文】 大分子）： 是一類生物大分子共價(jià)或非共價(jià)的結(jié)合，這種結(jié)合能顯著提高復(fù)合物的結(jié)構(gòu)與功能。 Covalent(共價(jià) ) or noncovalent associations of more than one major classes of large biomolecules which greatly increases the functionality or structural capabilities of the plex. 核蛋白 Nulceoprotein: nucleic acids + protein (Section A4) A3 Macromolecules 糖蛋白 Glycoprotein: carbohydrate + protein 脂蛋白 Lipoprotein: Lipid + protein A4 大分子的組裝 Protein plexes (蛋白質(zhì)復(fù)合體 ) Nucleoprotein (核蛋白 ) Membranes (膜 ) Noncovalent interactions 非共價(jià)相互作用 protein plexes 蛋白質(zhì)復(fù)合體 Long polymers of tubulin維管蛋白 . Schematic diagram showing the (a) crosssectional and (b) surface pattern of tubulin a and b subunits in a microtubule (microfilament) actin and myosin, ponents of muscle fibers as well keratin (cilia纖毛 and flagella鞭毛 ) A4 Large macromolecular Assemblies Noncovalent interaction 角蛋白 Crystal structure of 50S rRNA A4 Large macromolecular Assemblies Nulceoprotein 核蛋白 (1) associations of nucleic acids and protein Ribosome核糖體 : ribosomal proteins ＋ rRNAs ?Chromatin (染色質(zhì) ): ?Viruses: ?Telomerase (端粒酶 ) : ?Ribonuclease P： A4 Large macromolecular Assemblies DNA + 組蛋白 蛋白衣殼 + RNA or DNA 復(fù)制染色體末端 . RNA 作為復(fù)制模板 蛋白質(zhì) (催化 )合成反應(yīng) tRNA 突變 . Protein P ＋ RNA Nulceoprotein核蛋白 (2) Plasma membrane 質(zhì)膜 Noncovalent非 共價(jià) interactions The force of macromolecule assembly 大分子組裝的力 A4 Large macromolecular Assemblies 范德華力 van der Waals forces: noncovalent associations between uncharged molecules. *氫鍵 Hydrogen bonds (dipoledipole): nucleic acids *疏 水作用力 Hydrophobic interaction: proteins 電荷 電荷作用（鹽橋） : 帶電分子 電荷 偶極 ,偶極 偶極 :至少一方是一個(gè)偶極 .力弱。 色散力 : 非極性分子 CH3 (偶極 ) (uncharged molecules)
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