【正文】 ： a．幾何大小 500m3 的發(fā)酵罐徑高比為 3，即 H=3D， V=（ πD2/4）3D=100 ，得到直徑 D=，高 HL=。 b．傳熱面積 內蛇罐 36（ 6 組） ， F=562m3 c．攪拌器 攪拌器直徑： Dj=1/2D= 擋板寬度 ： B== 攪拌葉間距： S= =， 攪拌葉與罐底距離 C= Dj =。 C+3S=+3 =H L , 則取四層攪拌器。 2）公稱為 100m3 的發(fā)酵罐 a．幾何大小 100m3 的發(fā)酵罐徑高比為 ，即 H=， V=（ πD2/4）=100 ，得到直 徑 D=，高 HL=。 b．傳熱面積 內蛇罐 36（ 6 組） ， F=114m3 c．攪拌器 攪拌器直徑： Dj=1/3D= 擋板寬度 ： B== 攪拌葉間距： S=2Dj =， 攪拌葉與罐底距離 C= Dj =。 C+3S=+3 =H L , 則取四層攪拌器。 3) 公稱為 20 m3 的發(fā)酵罐 a．幾何大小 20 發(fā)酵罐的徑高比為 ，即即 H=， V=（ πD2/4）=100 ，得到直徑 D=，高 HL=。 b．傳熱面積 外盤管 40 ， F=40m3 c．攪拌器 攪拌器直徑： Dj=1/3D= 擋板寬度 ： B== 攪拌葉間距： S=2Dj =， 攪拌葉與罐底距離 C= Dj =。 C+3S=+2=H L , 則取三層攪拌器。 發(fā)酵罐圖如下： 、 圖 13 發(fā)酵罐 簡圖 1罐體； 6無菌空氣 所選擇的主要設備如下表： 表 5 所選主要設備 設備名稱 規(guī)格型號 數(shù)量（個） 生產廠家 二級發(fā)酵罐 500 m3 8 無錫市雪浪發(fā)酵工程設備廠 一級發(fā)酵罐 100m3 6 無錫市雪浪發(fā)酵工程設備廠 種子罐 20m3 3 無錫市雪浪發(fā)酵工程設備廠 6 車間總體布局 車間組成 通過對發(fā)酵車間設備構成以及工藝路線的研究，可以判斷發(fā)酵車間的主要有發(fā)酵罐間、 CIP 間、空氣凈化間、無菌水供應間、培養(yǎng)基原料處理間和配料間補料間等。 車間布局原 則 （ 1）最大限度的滿足工藝生產包括設備維修的要求； 年產 1 萬噸青霉素原料藥工廠發(fā)酵車間的設計 22 （ 2）有效的利用車間建筑面積（包括空間）和土地； （ 3）要為車間的技術經濟指標、先進合理以及節(jié)能等要求創(chuàng)造條件； （ 4）考慮其他專業(yè)對本車間布局的要求； （ 5）要考慮車間的發(fā)展和廠房的擴建； （ 6）車間中所采用的勞動保護、防腐、防火、防毒、防爆以及安全衛(wèi)生等措施是否符合要求； （ 7）本車間與其他車間在總平面圖上位置合理，力求使他們之間輸送管線最短，聯(lián)系最方便； （ 8）考慮廠房地區(qū)的氣象、地質、水文等條件； （ 9）人流、物流不能交錯。 車間布局圖 車間布局圖是根據(jù)以上工藝流程和設備選型，結合當?shù)氐臍夂驐l件和廠址選擇地點所設計的車間各部分大小和配備設施而設計的工程圖。由物料衡算和設備選型，此設計所布局的圖如附表。 致 謝 本論文是在導師的悉心指導下完成的。很長一段時間，恩師在我的學士學位課程學習，設計研究工作、教學活動、學術交流、論文撰寫和工作生活等方面都給予了極大的關懷和支持，并為我提供了良好的學習研究環(huán)境。導師的嚴謹治學、孜孜不倦、持之以恒的師表風范是我終身學習的楷模，在此向恩師表示誠摯的感謝和崇高的敬 意！ 感謝所有關心、幫助和支持我的老師、同學們！ 年產 1 萬噸青霉素原料藥工廠發(fā)酵車間的設計 24 參 考 文 獻 1 唐燕輝 .藥物制劑生產設備及車間工藝設計 .北京 :化學工業(yè)出版社 .2022 2 段開紅 .生物工程設備 .北京 :科學出版社 .2022 3 元英進 ,趙廣榮 ,孫鐵民 .北京 :化學工業(yè)出版社 .2022 4 夏煥章 ,熊宗貴 .北京 :高等教育出版社 .2022:259— 306 5 余龍江 .生物制藥工廠工藝設計 .化學工業(yè)出版社 . 6 蔡功祿。發(fā)酵工廠設計概論 .中國輕工業(yè)出版社 .2022 7 張洪斌，杜志剛 .制藥工程課程設計 .北京 .化學工業(yè)出 版社 .2022 8 李鈞 .藥品 GMP 文件化教程 .中國醫(yī)藥科技出版社 .2022 9 姚日生 ,梁世中 .制藥工程原理與設備。高等教育出版社 .合肥。 g an employment tribunal claim Employment tribunals sort out disagreements between employers and employees. You may need to make a claim to an employment tribunal if: ? you don39。t agree with the disciplinary action your employer has taken against you ? your employer dismisses you and you think that you have been dismissed unfairly. For more information about dismissal and unfair dismissal, see Dismissal. You can make a claim to an employment tribunal, even if you haven39。t appealed against the disciplinary action your employer has taken against you. However, if you win your case, the tribunal may reduce any pensation awarded to you as a result of your failure to appeal. Remember that in most cases you must make an application to an employment tribunal within three months of the date when the event you are plaining about happened. If your application is received after this time limit, the tribunal will not usually accept it. If you are worried about how the time limits apply to you, take advice from one of the anisations listed under Further help. Employment tribunals are less formal than some other courts, but it is still a legal process and you will need to give evidence under an oath or affirmation. Most people find making a claim to an employment tribunal challenging. If you are thinking about making a claim to an employment tribunal, you should get help straight away from one of the anisations listed under Further help. If you are being represented by a solicitor at the tribunal, they may ask you to sign an agreement where you pay their fee out of your pensation if you win the case. This is known as a damagesbased agreement. In England and Wales, your solicitor can39。t charge you more than 35% of your pensation if you win the case. If you are thinking about signing up for a damagesbased agreement, you should make sure you39。re clear about the terms of the agreement. It might be best to get advice from an experienced adviser, for example, at a Citizens Advice Bureau. To find your nearest CAB, including those that give advice by e mail, click on nearest CAB. For more information about making a claim to an employment tribunal, see Employment tribunals. The (lack of) air up there Watch mCayman Islandsbased Webb, the head of Fifa39。s antiracism taskforce, is in London for the Football Association39。s 150th anniversary celebrations and will attend City39。s Premier League match at Chelsea on Sunday. I am going to be at the match tomorrow and I have asked to meet Yaya Toure, he told BBC Sport. For me it39。s about how he felt and I would like to speak to him first to find out what his experience was. Uefa has opened disciplinary proceedings against CSKA for the racist behaviour of their fans during City39。s 21 win. Michel Platini, president of European football39。s governing body, has also ordered an immediate investigation into the referee39。s actions. CSKA said they were surprised and disappointed by Toure39。s plaint. In a statement the Russian side added: We found no racist insults from fans of CSKA. Age has reached the end of the beginning of a word. May be guilty in his seems to passing a lot of different life became the appearance of the same day。 May be back in the past, to oneself the paranoid weird belief disillusionment, these days, my mind has been very messy, in my mind constantly. Always feel oneself should go to do something, or write something. Twenty years of life trajectory deeply shallow, suddenly feel something, do it. 一字開頭的年齡已經到了尾聲。或許是愧疚于自己似乎把轉瞬即逝的很多個不同的日子過成了同一天的樣子；或許是追溯過去，對自己那些近乎偏執(zhí)的怪異信念的醒悟，這些天以來，思緒一直很凌亂，在腦海中不斷年產 1 萬噸青霉素原料藥工廠發(fā)酵車間的設計 26 糾纏。總覺得