篇第九章白血病ppt課件-資料下載頁
2025-01-05 15:39本頁面
【正文】 proteins PMLRARalpha Differentiation agents (alltrans retinoic acid, arsenic trioxide) Hyperleukecytosis: cause a batch of plications and should be treated using leukapheresis ( exchanging transfusion) or preinduction treatment prior to intensive chemotherapy Acute leukemia over 60 years of age is less responsive to chemotherapy Standard twodrugs therapy can be used. CR 30% Intolerant to standard therapy. Lowdose of AraC can be used for 1428 days Therapy of the CNS leukemia The CNS is a frequent sanctuary site for leukemic cells because most of the chemotherapy drugs are not able to reach the CNS. Some types of acute leukemia have tendency to be with CNS leukemia such as AML (M4, M5), ALL Intrathecal chemotherapy Cranial irradiation Stem cell transplantations The main purpose of BMT and PBSCT in cancer treatment is to make it possible for patients to receive very high doses of chemotherapy and/or radiation therapy. In addition, reestablished normal hematopoiesis and immune system by the healthy stem cells fight against leukemia effectively. So it change the vision in the medical history that leukemia is incurable malignancies Three types of transplantation performed Allogeneic transplantation (HLAmatched individual donors) Syngeneic transplantation: identical twins Autologous transplantation: patients receive their own stem cells Clinical results of stem cell transplantation 0%10%20%30%40%50%60%70%80%90%1 2 3AML ALL CML Fiveyears disease free survival rate Transplantation Chemotherapy Chronic myelogenous leukemia (CML) Future directions 復(fù)習思考題 ？ ？為何要進行鞏固、 強化化療？ 、臨床表現(xiàn)、與急性 白血病的關(guān)系？
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