中西醫(yī)結(jié)合治療腦梗死的策略-資料下載頁
2025-10-03 12:54本頁面
【導(dǎo)讀】中風(fēng)——腦血管病。“故生之來謂之精，兩精相搏謂之神”。“人始生，先成精，精成而腦髓生，骨為干，脈為營(yíng)，筋為剛，肉為墻，皮膚堅(jiān)而毛發(fā)長(zhǎng)”?！把?，神氣也”。《靈樞·營(yíng)衛(wèi)生會(huì)》?！叭酥浶越栽谀X中”?？鄥ⅫS連丹參益母草。木犀草素水飛薊素姜黃黃芩。脂溶性的丹參酮類。抑制腦組織炎癥反應(yīng)。減輕腦梗死面積、腦水腫。上調(diào)抗氧化應(yīng)激因子Nrf2和HO-1. 下調(diào)炎癥因子TLR4/TLR2/MyD88/NF-κB. 抑制神經(jīng)細(xì)胞凋亡。保護(hù)缺血區(qū)線粒體。老藥新用途——腦保護(hù)作用機(jī)制。中西醫(yī)結(jié)合——治療腦梗死新策略。降低病死率、致殘率，提高治愈率。推動(dòng)中醫(yī)藥的現(xiàn)代化發(fā)展和國(guó)際化進(jìn)程
【正文】 nhibition of sonic hedgehog signaling aggravates brain damage associated with the downregulation of Gli1, Ptch1 and SOD1 expression in acute ischemic stroke. Neuroscience Letters, 2020。506(1):16 13. Luteolin downregulates TLR4, TLR5, NFκB and pp38MAPK expression, upregulates the pERK expression, and protects rat brains against focal ischemia. Brain Research 2020 Apr 11。1448:7181. 14. Protective effect of celastrol in rat cerebral ischemia model: downregulating pJNK, pcJun and NFκB. Brain Research, 2020。1464:813 15. Neuroprotective effect of early and shorttime applying sophoridine in pMCAO rat brain: Downregulated TRAF6 and upregulated pERK1/2 expression, ameliorated brain infaction and edema. Brain Res Bull. 2020； 88： 379384 16. Protective effect of luteolin in experimental ischemic stroke: upregulated SOD1, CAT, Bcl2 and claudin5, downregulated MDA and Bax expression. Neurochemical research. 2020 Sep。37(9):202024. 15 謝 謝！
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