中西醫(yī)結合治療腦梗死的策略-資料下載頁
2025-10-03 12:54本頁面
【導讀】中風——腦血管病?！肮噬畞碇^之精，兩精相搏謂之神”?！叭耸忌?，先成精，精成而腦髓生，骨為干，脈為營，筋為剛，肉為墻，皮膚堅而毛發(fā)長”?！把?，神氣也”?！鹅`樞·營衛(wèi)生會》。“人之記性皆在腦中”。苦參黃連丹參益母草。木犀草素水飛薊素姜黃黃芩。脂溶性的丹參酮類。抑制腦組織炎癥反應。減輕腦梗死面積、腦水腫。上調抗氧化應激因子Nrf2和HO-1. 下調炎癥因子TLR4/TLR2/MyD88/NF-κB. 抑制神經細胞凋亡。保護缺血區(qū)線粒體。老藥新用途——腦保護作用機制。中西醫(yī)結合——治療腦梗死新策略。降低病死率、致殘率，提高治愈率。推動中醫(yī)藥的現代化發(fā)展和國際化進程
【正文】 nhibition of sonic hedgehog signaling aggravates brain damage associated with the downregulation of Gli1, Ptch1 and SOD1 expression in acute ischemic stroke. Neuroscience Letters, 2020。506(1):16 13. Luteolin downregulates TLR4, TLR5, NFκB and pp38MAPK expression, upregulates the pERK expression, and protects rat brains against focal ischemia. Brain Research 2020 Apr 11。1448:7181. 14. Protective effect of celastrol in rat cerebral ischemia model: downregulating pJNK, pcJun and NFκB. Brain Research, 2020。1464:813 15. Neuroprotective effect of early and shorttime applying sophoridine in pMCAO rat brain: Downregulated TRAF6 and upregulated pERK1/2 expression, ameliorated brain infaction and edema. Brain Res Bull. 2020； 88： 379384 16. Protective effect of luteolin in experimental ischemic stroke: upregulated SOD1, CAT, Bcl2 and claudin5, downregulated MDA and Bax expression. Neurochemical research. 2020 Sep。37(9):202024. 15 謝 謝！
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