[臨床醫(yī)學(xué)]鈣通道阻滯藥物-資料下載頁
2025-10-07 17:17本頁面
【正文】 chemia, subarachnoid hemorrhage Amlodipine (氨氯地平 ) ? Act slowly but lasting, t1/2 = 35 ~ 50 hours ? Bioavailability: 60% ~ 65% ? Therapeutic use: hypertension and angina Verapamil (維拉帕米 / Isoptin, 異博定 ) ? 負(fù)性肌力作用 阻滯鈣通道、激活磷酸二酯酶、抑制收縮蛋白的功能 ? 負(fù)性頻率作用 ? PR 間期 ↑— 劑量依賴性 ? 擴(kuò)張血管 外周阻力血管與冠狀動脈 反射性交感神經(jīng)興奮作用輕 臨床應(yīng)用 1. Supraventricular tachycardia 2. Angia (variant) 3. Hypertension 4. Hypertrophic myocardiopathy 不良反應(yīng) 1. Constipation, flush, headache, itch 2. Large doses: atrioventricular blockade 3. Most serious: hypotension () A. Actions 1. Negative inotropic effect 2. Negative chronotropic effect 3. Vasodilation of coronary artery and its branches, and peripheral resistant vessels 4. Ameliorates myocardial metabolism and protects the function of mitochondria Diltiazem (地爾硫 ) 卓 B. Therapeutics uses 1. Supraventricular tachycardia 2. Variant angina and angina of effort 3. Hypertension 4. Hypertrophic myocardiopathy C. Adverse reaction Rash, constipation, headache, flushing, dizziness, angioneurotic edema (血管神經(jīng)性水腫 ) D. Contraindications The same as verapamil
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