止血障礙血栓形成ppt課件(編輯修改稿)
2025-02-01 12:19 本頁(yè)面
【文章內(nèi)容簡(jiǎn)介】 Hereditary/Acquired ? Factor V Leiden ? Prothrombin 20210 ? Protein C ? Protein S ? Antithrombin III ? Dysfibrinogenemia ? Hyperhomocysteinemia ? PAII ? Platelet glycoprotein IIb/IIIa Factor V Leiden ? Mutation at position 506 rendering FV insensitive to degradation by activated protein C. ? Autosomal dominant。 5% Caucasian population. ? Heterozygote 7x increased risk for venous thrombosis ? Homozygote 80x increased risk ? Often found in association with other risk factors protein C and S deficiencies Prothrombin 20210 Mutation ? Mutation results in increased synthesis of prothrombin resulting in elevated plasma levels of biochemically normal prothrombin ? Autosomal dominant。 12% of population ? Increased risk of venous thrombosis 2x Protein C Deficiency ? Autosomal dominant ? Mutation results in mild to severe deficiency。 increase risk for venous thrombosis homozygote = purpura fulminans ? % of US population ? Acquired DIC, liver disease, oral contraceptives, oral anticoagulant use Protein
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