止血障礙血栓形成ppt課件(已修改)
2025-01-17 12:19 本頁面
【正文】 Disorders of Hemostasis: Thrombosis John Lazarchick, . Director, Hematopathology/Hemostasis August 30, 2022 Hypercoagulability ? Definition: Alteration in the hemostatic balance between blood fluidity and clot formation. This is due to geic and acquired disorders which shift this balance toward excessive or inappropriate platelet aggregation and fibrin formation and predispose to thrombosis. Prethrombotic States ? 10 inherited abnormalities resulting from mutations affecting the function of coagulant proteins and natural inhibitors ? 20 acquired defects that either affect the endothelium, fluid flow or blood ponents. These defects are often superimposed on 10 defects Hypercoagulability: Prethrombotic States ? Virchow (1856) – Abnormalities of blood vessels – Abnormalities of fluid flow – Abnormalities of blood ponents Blood Vessel Abnormalities ? Endothelial cell antithrombotic properties PGI2, NO2, TFPI, PAI1, heparans, thrombomodulin ? Geic predisposition and acquired defects in these functions increase the risk of arterial and venous t
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