分子生物學(xué)43592842-wenkub
2023-01-20 03:23:10 本頁面
【正文】 ated Kinase/Protein Kinase B/Nuclear FactorκB PathwayMolecular Biology of the CellVol. 17, 3534–3542, August 2023Guiyuan Li et al. 0711078 曹廣超LRRC4 gene which contains a conserved leucinerich repeat (LRR) cassette and an immunoglobulin (Ig) IgC2 domain, is associated with glioma suppression both in vitro and in vivo. The present study provides evidence that the conspicuous absence of LRRC4 in highgrade gliomas directly contributes to the increasing tumor grade. The loss of LRRC4 in U251 cells is caused by the loss of homozygosity at chromosome 7q32ter. It was also found that LRRC4 requires a functional LRR cassette domain to suppress U251 cell proliferation. In the LRR cassette domain, the third LRR motif of
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