分子生物學(xué)43592842-文庫(kù)吧資料
2025-01-05 03:23本頁(yè)面
【正文】 ributes to the increasing tumor grade. The loss of LRRC4 in U251 cells is caused by the loss of homozygosity at chromosome 7q32ter. It was also found that LRRC4 requires a functional LRR cassette domain to suppress U251 cell proliferation. In the LRR cassette domain, the third LRR motif of the core LRR is found to be indispensable for the function of LRRC4.? The inhibitory effect of LRRC4 is acpanied by a decrease in the expression of pERK, pAkt, pNFBp65, signal transducer and activator of transcription protein3 (STAT3), and mutant p53, and an increase in the expression of cJun NH2terminal kinase (JNK)2 and pcJun, suggesting that LRRC4 plays a major role in suppressing U251 cell proliferation by regulating the extracellular signa
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