黃酮類化合物和腦健康-wenkub
2023-06-10 22:12:19 本頁面
【正文】 ynthesis Hippocampus Cortex Storage Spencer et al: Proceed Nutr Soc, 2022。 Nutr, 2022。 O126: 10 mM。 Schroeter et al: Biochem J, 2022 Flavonoid Activation of Prosurvival Signalling vehicle mM 44 42 pERK1/2 Total ERK ( 15 min。 Nutr, 2022。 Brit. J. Nutr. 2022 3’Omethylepicatechin O C H 3O HOH OO HO HEpicatechin7sulphate O HO HOOO HO HSOOOEpicatechin7bD glucuronide O HO HOO HO HC O O HO HOOO HO HEpicatechin O HO HOH OO HO H Plasma concentration mM Major Flavonoid Metabolites Brain Uptake of Flavonoids 00 . 511 . 522 . 53T o ta lG SHV i ta m i nEV i ta m i nCmmol/g brain tissue00 . 0 40 . 0 80 . 1 20 . 1 60 . 2Pe l a r g o n i d i nnmol/g brain tissueAbd el Mohsen et al: FRBM, 2022。 n=14). Subjects : 1830 yrs Subjects: 6075 yrs 36 40 44 48 52 56 60 Flavonoid Placebo * GoNoGo task: measures Executive function/attention Predrink 1h post 5h post Flavonoid Placebo * 36 40 44 48 52 56 60 Predrink 1h post 5h post Mean no. of correctly detected targets How are these effects mediated? Proposed mechanisms underlying the neuroprotective effects of flavonoids Antioxidant effects Modulation of Receptor Function Modulation of Neuronal and glial signalling Modulation of Membrane Fluidity Influences on gene expression Inhibitors of Neuroinflammation Biotransformation of flavonoids Oral Ingestion of flavonoid Monomeric units Oligomeric Flavonoids Stomach Small Intestine jejunum ileum Colon Liver Kidney Urine Portal vein Renal excretion of glucuronides Oligomers cleaved cells Bloodbrain barrier Neurons glia glucuronides Aring glucuronides aglycone Omethylated glucuronides Omethylated glucuronides Omethylated Sulphates Further metabolism Phenolic acids Gut microflora Flavonoid Spencer , et al: Antiox Redox Signal, 2022。 University of Reading 2022 Molecular Nutrition Group School of Chemistry, Food and Pharmacy 23 June 2022 Flavonoids and Brain Health: Multiple effects underpinned by mon mechanisms Dr. Jeremy P E Spencer 8089 7079 6069 3559 Prevalence of AD (%) Age (years) Prevalence of PD (%) 1900 1920 1940 1960 1980 2022 202040455055606570758085Life Expectancy at
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