黃酮類化合物和腦健康(存儲版)
【正文】 02: 35 mM 0 basal EC 300 nM EC 300 nM UO126 EC 300 nM LY294002 EC 300 nM LY294003 UO126 Relative band intensity pCREB (Ser133) MEK inhibitor PI3K inhibitor OO HO HO HH OO HOONOLY294002 OOO HH 2 NPD98059 Epicatechin PI3 Kinase Inhibitor MEK Inhibitor OO HO HO HO HH OOQuercetin Similarity between flavonoids and kinase inhibitors Flavonoid interactions with neuronal and glial signalling IFN? IL1b TNFa CD23 p38 STAT1 iNOS NO ? TNFa Caspase8 Caspase9 Caspase3 Neuronal Apoptosis ROS/RNS Microglia/Astrocyte Neuron ASK1 JNK1/2 BAD BclxL DHBT1 ERK1/2 Akt MEK1/2 PI3K CREB Activation by Flavonoids Scavenging by Flavonoids Inhibition by Flavonoids Activation Inhibition CysDA Vafeiadou et al: EMID Drug Targets, 2022。 Brit J Nutr, 2022。 J Nutr, 2022。 Biochem J, 2022。 Chem Soc Rev, 2022 Flavonoid Attenuation of Death Signalling *** 0 Band intensity *** Band intensity Band intensity Band intensity basal 54 H2O2 3’MEC 46 active JNK total JNK Flavonoid: mM OS: Peroxide: 50 mM H2O2 H2O2 EC basal H2O2 3’MEC H2O2 H2O2 EC Spencer et al: Biochem J, 2022。 ABB, 2022 Vauzour et al: J Neurochem, 2022。 Nutr, 2022。 Schroeter et al: Biochem J, 2022 Flavonoid Activation of Prosurvival Signalling vehicle mM 44 42 pERK1/2 Total ERK ( 15 min。 Brit. J. Nutr. 2022 3’Omethylepicatechin O C H 3O HOH OO HO HEpicatechin7sulphate O HO HOOO HO HSOOOEpicatechin7bD glucuronide O HO HOO HO HC O O HO HOOO HO HEpicatechin O HO HOH OO HO H Plasma concentration mM Major Flavonoid Metabolites Brain Uptake of Flavonoids 00 . 511 . 522 . 53T o ta lG SHV i ta m i nEV i ta m i nCmmol/g brain tissue00 . 0 40 . 0 80 . 1 20 . 1 60 . 2Pe l a r g o n i d i nnmol/g brain tissueAbd el Mohsen et al: FRBM, 2022。 University of Reading 2022 Molecular Nutrition Group School of Chemistry, Food and Pharmacy 23 June 2022 Flavonoids and Brain Health: Multiple effects underpinned by mon mechanisms Dr. Jeremy P E Spencer 8089 7079 6069 3559 Prevalence of AD (%) Age (years) Prevalence of PD (%) 1900 1920 1940 1960 1980 2022 202040455055606570758085Life
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