【醫(yī)學(xué)課件】感染性心內(nèi)膜炎ppt課件(已修改)
2025-10-26 06:53 本頁面
【正文】 7/98 1 Update on Infective Endocarditis Larry Baddour, MD University of Tennessee ： ； :； ： 7/98 2 Pathogenesis ? Disruption of the endocardial layer as a plication of abnormal blood flow associated with underlying cardiac defect ? Bacteriumendothelium interaction with bacterial attachment and invasion of endothelial cells ： ； :； ： 7/98 3 Epidemiology ? Underlying valvular abnormality predisposing to infective endocarditis – rheumatic fever a mon cause in the past – mitral valve prolapse currently represents the most mon underlying cardiac abnormality 7/98 4 mitral valve prolapse ? risk for infective ednocarditis is ?5x8x ? mitral regurgitation increases the risk ? leaflet redundancy with myxomatous degeneration is a frequent finding ? age 20 , female predominate age 20 , male accounts for 60% age 50 , male accounts for 68% 7/98 5 Mitral Valve Prolapse and Infective Endocarditis 024681012141618201 9 2 0 2 9 3 0 3 9 4 0 4 9 5 0 5 9 6 0Male Female Rev Infect Dis 1986。8:117137 7/98 6 Coagulasenegative Staphylococci ? can produce nativevalve endocarditis in mitral valve prolapse ? usually subacute, difficult to diagnose, and disregarded as a contaminant ? delay in diagnosis and treatment may account for the severe plications – myocardial abscess formation – valvular insufficiency requiring valve surgery – death 7/98 7 Prosthetic Heart Valve ? positive blood culture in hospitalized patients
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