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? 影響胃酸的分泌 Hp致病機(jī)制 ? CagA (cytotoxin associated protein ? VacA (vacuolating cytotoxin) ? SabA(sialicacidbinding adhesin) BabA(Blood group antigenbinding adhesion ) ? OipA (outer inflammatory protein A) ? Interfernce of microRNA expression ? Ammonia, lipopolysaccharide, inflammatory mediator ? Phosphatase A, urease virulence factors Overview of H. pylori factors that interfere with host cell functions Wroblewski LE, et al., Targeted disruption of the epithelialbarrier by H. pylori. Cell Communication and Signaling 2022,9:29 Disruption of Epithelial cell junctionbased barrier Disruption of Epithelial cell junctionbased barrier Disruption of Epithelial cell junctionbased barrier Backert S,et al., Molecular mechanisms of gastric epithelial cell adhesion and injection of CagA by H. pylori. Cell Communication and Signaling 2022,9:28 Disruption of Epithelial cell junctionbased barrier TLR, NOD, and the NF?B signaling patrway Regulation of cell cycle progression Signaling cascades that regulate the intrinsic and extrinsic pathway of apoptosis Progression to gastric adenocarcinoma induced by infec