【正文】 ernce of microRNA expression ? Ammonia, lipopolysaccharide, inflammatory mediator ? Phosphatase A, urease virulence factors Overview of H. pylori factors that interfere with host cell functions Wroblewski LE, et al., Targeted disruption of the epithelialbarrier by H. pylori. Cell Communication and Signaling 2022,9:29 Disruption of Epithelial cell junctionbased barrier Disruption of Epithelial cell junctionbased barrier Disruption of Epithelial cell junctionbased barrier Backert S,et al., Molecular mechanisms of gastric epithelial cell adhesion and injection of CagA by H. pylori. Cell Communication and Signaling 2022,9:28 Disruption of Epithelial cell junctionbased barrier TLR, NOD, and the NF?B signaling patrway Regulation of cell cycle progression Signaling cascades that regulate the intrinsic and extrinsic pathway of apoptosis Progression to gastric adenocarcinoma induced by infection HCO3－粘液屏障 H＋ 反彌散 致密連接破壞 離子交換紊亂 上皮細胞損傷粘液分泌減少 損害因素 尿素酶 NH3 阻斷胃酸對胃泌素分泌反饋抑制 G細胞敏感性增強 炎癥直接刺激 CCK對 G細胞分泌反饋抑制障礙。 ? 球形變結(jié)構(gòu)改變：球形 Hp缺乏完整細胞結(jié)構(gòu)，菌體表面分泌多聚糖，形成一層黏液樣生物膜，彼此黏附；球形變 Hp DNA指紋圖譜不變。Advanc