hp診治進(jìn)展ppt課件(專(zhuān)業(yè)版)
【正文】 ? Located in gastric epithelium ? Negative Gram stain ? Sshipped /arcshipped/ spherical（ sometime） ? 47 monopole flagella ? Microaerobic envirement Biological character of H. pylori Hp球形變的研究 ? 球形變誘因：在營(yíng)養(yǎng)缺乏，有氧脅迫，延期培養(yǎng)，亞致死劑量抗生素， pH 值改變等。 ? 球形變意義：失去藥物作用靶點(diǎn)；逃避免疫攻擊。 Th2。 neutrophilactivating protein (NAP) Helicobacter pylori and obesity H. pylori infection leads to chronic active gastritis H. pylori infection leads to a decrease in circulating ghrelin and to an increase in gastric leptin Helicobacter pylori and GERD Thank you for your attention 。 Infection an Colonization ? Chronic gastritis ? Peptic ulcer ? Gastric adenocarcinoma ? MALT lymphoma ? gastroesophageal reflux disease？ ? functional dyspepsia？ ? idiopathic thrombocytopenic purpura ? irondeficiency anemia H. pylorirelated diseases ? Hp損害胃黏膜屏障 ? Hp誘導(dǎo)炎癥和免疫反應(yīng) ? Hp基因片斷整合到宿主細(xì)胞 DNA ? 影響胃酸的分泌 Hp致病機(jī)制 ? CagA (cytotoxin associated protein ? VacA (vacuolating cytotoxin) ? SabA(sialicacidbinding adhesin) BabA(Blood group antigenbinding adhesion ) ? OipA (outer inflammatory protein A) ? Interf
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