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【正文】 SCHULTE H。 70: 733737 Incidence of CAD vs LDL/HDL ratio by TG level (n = 4559) PROCAM Heart Study 0 50 100 150 200 250 300 3 4 5 5 6 7 LDL/HDL ratio CHD Incidence/1000 in 6 years CHD risk according to LDL/HDL ratio at baseline ASSMANN G。 MMV Medizin Verlag, 1993: 43 5 High CHD risk Medium CHD risk Low CHD risk 35 3 PROCAM Heart Study Mean values for developing atherosclerotic CHD within 6 years Variable CHD Development No CHD Development (n = 186) (n = 4221) TC (mg/dl) HDLC (mg/dl) LDLC (mg/dl) LDL/HDL ratio TG (mg/dl) ASSMANN G。 MMV Medizin Verlag, 1993: 41 PROCAM Heart Study Predictive value of risk factors for developing atherosclerotic CHD within 6 years Variable Risk Ratio Predictive Power % TG ? 200 mg/dl TC ? 250 (mg/dl) LDLC ? 195 (mg/dl) LDLC ? 155 (mg/dl) HDLC ? 35 (mg/dl) LDL/HDL ratio ? 5 ASSMANN G。 MMV Medizin Verlag, 1993: 43 PROCAM Heart Study HDL as CHD risk factor showed 186 events, in men aged 40 60 years (n = 4407) CHD Incidence per 1, 000 in 6 years 0 20 40 60 80 100 120 140 160 ? 35 35 55 ? 55 HDLC (mg/dL) 110 30 21 ASSMANN G。 MMV Medizin Verlag, 1993: 59 PROCAM Heart Study LDL as CHD risk factor showed 177 events in men aged 40 60 years, ( n = 4263) CHD Incidence per 1, 000 in 6 years 0 20 40 60 80 100 120 140 ? 135 135 154 155 195 ? 195 LDLC (mg/dL) 54 30 16 31 120 ASSMANN G。 MMV Medizin Verlag, 1993: 60 PROCAM Heart Study Expert Opinions Part IV The Lipid Triad Expert Comments AHA, November 1999 “Evaluating the risk on the bases of LDL alone, is naive” Valentin Fuster, Mount Sinai Medical Center, New York “The LDL/HDL ratio is a much stronger predictor for the CHD risk than LDL alone” Paul Ridker, Brigham Institute for Women’s Hospital, Boston ACCP, March 2022 “Low HDL is a better indicator of CHD than high LDL as seen in epidemiological studies such as the Framingham Study and recently the VAHIT
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