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【正文】 Study.” Sander Robins, University Medical Center, Boston “Landmark statin trials have shown consistent benefits on CHD reduction after raising HDL by 5 10% irrespective of LDL levels” Christie Ballantyne, Baylor College of Medicine, Houston The Lipid Triad Expert Comments Helsinki Heart Study “The LDL/HDL ratio was the best single predictor of cardiac events” Manninen V, Leena T, Koskinen P et al. Circulation 1992。 Eur Heart Journal 1998, 19 A2A11 “For practical purposes it appears advisable to base predictions for atherosclerotic CAD and treatment decision on a full lipid profile, (cholesterol, triglycerides, LDL and HDL cholesterol) rather than cholesterol or LDL cholesterol determinants alone” Gerd Assmann, Lipid Metabolism Disorders and Coronary Heart Disease, MMV Medizin Verlag, 1993 The Lipid Triad Expert Comments State of the Art Conference, Berlin April 2022 “The Lipid Triad should form the bases of diagnostic and therapeutic decisions in lipid therapy” Markolf Hanefeld, Institute for Metabolism Disorders and Research, Dresden “By just using high LDL as a criterion for prescription, some patients are receiving statin treatment who do not need it, and those with low HDL and high LDL who do need the treatment are not getting it!” Gerd Assmann, Institute of Clinical Chemistry and Lab Medicine, M252。 Opinion 2022。 Opinion 1999。 144 (S 1): A 37 20,0 10,0 0,0 30,0 40,0 5 Placebo 35,0 25,0 15,0 5,0 Apo B/ Apo A1 Cerivastatin Pooled Data Data on file n = 588 n = 259 n = 265 n = 573 n = 658 n = 599 2,0 Patient Group Cerivastatin Placebo 100mg 200mg 300mg 400mg 800mg All Male Female ? 40 Years 40 65 Years ? 65 Years Elderly patients male female Cerivastatin Studies 8 Weeks Minimum Treatment Data on file Sales supporting activities Gaining consensus from OL Leading instead of Following Database LDL/HDL ratio Opinion Leaders Private Cardiologists GPs Spreading the Story Effectively Press Inter Publications
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