【正文】
Thus, the time to explore all of conformational space = 5 x 1047/1013 = 5 x 1034 seconds = x 1027 years age of universe ? This is known as the Levinthal paradox. Models of Protein Folding Framework model of protein folding Supported by experimental observation of rapid formation of secondary structure during protein folding process N C Framework model of protein folding N C Formation of individual secondary structure elements Framework model of protein folding N C Coalescence and rearrangement of individual secondary structure elements Nuclear condensation model N C Supported by protein engineering studies and various theoretical calculations Nuclear condensation model N C Formation of a nucleus of hydrophobic residues Nuclear condensation model N C Expansion of nucleus Framework and Condensation models are extremes on a continuum Framework (or diffusioncollision): 2186。 structure Nucleation condensation: Concerted consolidation of 2186。 structure as nucleus expands Con