【正文】
L門冬酰氨酶 抑制蛋白合成,5氟胞嘧啶 抑制dTMP合成,博萊霉素 損傷DNA及阻礙修復(fù),烷化劑,順鉑,絲裂霉素 與DNA交叉聯(lián)合,柔紅霉素,依托泊苷,安吖啶 抑制DNA合成,放線菌D 嵌入DNA,抑制RNA合成,長春新堿 抑制微管功能,激素類,第四頁,共四十頁。)嘌呤合成 抑制dTMP合成,阿糖胞苷 抑制(y236。ng) 6硫鳥嘌呤 抑制嘌呤合成,甲氨蝶呤 抑制(y236。,6硫嘌呤(pi224。,免疫(miǎny236。nɡ)應(yīng)用,第一頁,共四十頁。趙久良 北京協(xié)和醫(yī)院風(fēng)濕(fēnɡ shī)免疫科,免疫抑制劑的臨床(l237。n chu225。,Immunosuppressive drugs,dampen the immune system—notably T and B lymphocytes—functionally and/or numerically but do not permanently correct the fundamental imbalance of immune regulation in autoimmune disease.,第二頁,共四十頁。)抑制劑的共性,Effective and indispensable as remissioninducing and maintenance agents in the management of inflammatory rheumatic conditions. Constitute a heterogeneous group of compounds, each with a unique mode of action and toxicity profile. Associated with an increased risk of bacterial, viral, and fungal infection,第三頁,共四十頁。ol236。zh236。zh236。,硫唑嘌呤 抑制(y236。)嘌呤合成,甲氨蝶呤 抑制嘌呤(pi224。ng)合成 抑制dTMP合成,來氟米特 抑制(y236。)dTMP合成,環(huán)磷酰胺 與DNA交叉聯(lián)合,激素類 抑制炎癥因子,霉酚酸酯 阻斷嘌呤合成,鈣調(diào)蛋白抑制劑 損傷DNA及阻礙修復(fù),第五頁,共四十頁。,環(huán)磷酰胺CYC,機(jī)制:烷化劑,細(xì)胞周期非特異性細(xì)胞毒藥物 減少T及B細(xì)胞數(shù),抑制細(xì)胞分化及增殖 明顯抑制淋巴(l237。,干預(yù) 平均(p237。li225。li225。,AAV誘導(dǎo)