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1. Etiology 90% viruses, the majority of colds. rhinoviruses ,coronaviruses. parainfluenza virus, adenovirus, enterovirus, respiratory syncytial virus. 2. season fall and winter 3. Frequency three to eight colds a year. 12 Inoculation by virus Invasion of epithelium of Release of nasopharynx,sinuses and URT cellular damage Inflammatory of nasopharynx mediators in Cholinergic nasal secretions stimulation Increased Increased vascular mucus Permeability production bronchial constriction Nasal Rhinorrhea postnasal Stuffiness drip sore cough throat Pathophysiology of the mon cold 13 The clinical manifestation ? Common cold ? congestion ? a runny nose ? sneezing ? Cough,sore throat ? sometimes vomiting and diarrhea ? Fever,malaise,abdominal pain 14 ? Specific type of URI ? Herpangina:coxsackieviruses group A. summer / fever, sore throat, 14mm vesicles /ulcers on anterior tonsillar pillars, softpalate,uvula,tonsils pharyngeal wall. ? Pharyngoconjunctival fever :type 3,7 adenovirus, spring /summer. High fever, sore throat, pharyngitis, conjunctivitis, cervical lymphadenopathy. 15 Complications sinusitis otitis media cervical lymphadenopathy Mesentery lymphadenopathy retropharngeal abscess pneumonia rheumatic fever acute glomerulonephritis 16 Differential diagnosis ?Flu ?Appendicitis ?Early phase of acute infectious disease 17 Cold Flu Low or no fever High fever Sometimes headache Commonly headache Stuffy, runny nose Sometimes stuffy nose Sneezing Sometimes sneezing Mild, hacking cough Cough, may progress Slight aches and pains severe aches and pains Mild fatigue Fatigue, may persist Sore throat Sometimes sore throat 18 Treatment ? increased fluid intake