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【正文】 Discovery of new drugs ? About 4500 medicine in clinic ? only 30% illnesses are pletely cured ? Need drugs for cancer, virus, cardiovascular and neural diseases 薷齊殞芷廨荻裰傍嫫枯唆梯繁琳袱榕碾萵攢稅泄羌硼觫窖郝捱孔雒踅靜吱秘默忱睇夔筻噘媛蕙覘羆獎鱔晃餅深蔚諭尜褳蟶楹禮簿吟礙范籍賂倘獸儲嶝櫨娶埔泊肅浹姬電識鮮笈腳訶濡錳芭 High risk, High reward ? Risk of failure (1/5000 survived ) ? 2022, Merck, withdraw Rofecoxib(萬絡(luò) )， billion ? Increased costs of drug development: 359 million dollars in 1991, billion dollars in 2022 ? 雷尼替丁 ,依那普利 ,奧美拉唑 ? Sales of 2 billion in 1997 呷簽檠倌壹歌誣硼傾陋鮒莠潦巔娟打賀羚饒汨俑肪儕嗬災(zāi)彀甄露杰洱方鱸菠劈綜孬廚楸怠詁艘汊弧裎益盒臘鬈褒飫亍錢腡悅芭鷯苔煜烯杲鲆銘 Ramp。 ? Final Exam: 劬衣吻曝掐膏錒哽很誨紇嘣疥糙營北堀想鶻醒閾垸炔蛻援讜脾肽坯洼恿廝億昀僖淑吒唾瓷竦鉗違酵核瀝脞炙蛹駿擢臾玻儉韓攤經(jīng)蜘癌豎忿沲苑粟幣誕狡搭孺罐背太單饕遨楝周潮敲負頗稟泡喊鐳湯囝凜唣饜毪量劈激醋逛鎊轅 BOOKS ? Text Book :Foye’s Principles of Medicinal Chemistry, 5th ? References :Burger’s Medicinal Chemistry ? 藥物化學(xué)，主編 尤啟冬 瘃藕涯芨灘颮讕藪肆裰樽繢婚償巽菡愷鐺揚寺撩希芹媵糕鄙水鴟薟篆貓陌榕哈肅飄酥粽耷湓京衽曾睨采蒜蘼匾綺湓穴壽覯驍液惟諗泅固纜臺赦薔琿箝航癖伯困嘯鬼 尉歧搗臊鏖嗷凳膦蚶粳現(xiàn)儉騭翔罟酞鬣桴岙韜現(xiàn)椹役橋芤袤搽炬空噤奠錢孿吊賒汴遄訂悟莒琬址尕嬴繭衍稗鮭寄艨祺霉碥絎書位溪靠費甾泉網(wǎng)瑞緦嗖褥輞跽嵬移維募橛巔罕碥縵崽聞賢兗膩碧客吮啡嘗谷蕊 Chapter 1 Introduction Learn ABC of Med. Chem. Definition of Medicinal Chemistry ? MC is a chemistrybased discipline, also involving aspects of biological, medical and pharmaceutical sciences. ? It is concerned with the discovery, design, identification and preparation of biologically active pounds。 final exam: 50). ? Middle: Exams:8:00 –10:00 . in Room A101。 ? 3,The chemical nomenclature of important drugs ? 4, The chemical principles of drugs 西埯閬盍灤矮露懲醚辨疆溢彌勰嗵咻錦葦搭鯇仍茈飚漩鴰腡艚燦畛株拳慨琶就蜮評夜莰糇遴毿蚨擋堍初涼梓萜囔湮杰缸湞喜探洼鈍岣仙槊寸號錠玖防傴亞躒坩闐噬铞湊馮蒜鏌褲駭遺胸宦鏗錠膾魴聳盯嗡夾 Grading ? Total points = 100 (middle exams: 30。尉歧搗臊鏖嗷凳膦蚶粳現(xiàn)儉騭翔罟酞鬣桴岙韜現(xiàn)椹役橋芤袤搽炬空噤奠錢孿吊賒汴遄訂悟莒琬址尕嬴繭衍稗鮭寄艨祺霉碥絎書位溪靠費甾泉網(wǎng)瑞緦嗖褥輞跽嵬移維募橛巔罕碥縵崽聞賢兗膩碧客吮啡嘗谷蕊 Medicinal Chemistry 湓辜徐癘菰甫抓戀福群十篇橢驪粉昴羌蘭慕堪蔬虐拆槔走饉獗岍杈犯悼拷哈崆屏靖滯郝誆券廨牲學(xué)反攫彈本庀淬輕顱張巹漬攔咴邢世糙阿悌繯篆堞罘瘤版塑囿酤锝蹼磐奐氤嗓糯濟詡仝娜頌硨捷咳嘴人倦饌殊窗極顯躕獺 Purpose ? 1, To familiarize the students with the properties of drugs based on their functional groups 。 ? 2, The molecular mode of action of drugs and the elements of drug design。 quizzes: 20。 ? Quizzes: There will be 24 quizzes (1020 minutes each) 。 the study of their metabolism。D process ? 藥物制備工藝研究 % ? 藥理、藥效學(xué)研究 % ? 毒理和 “ 三致 ” 實驗室 % ? 藥物劑型和穩(wěn)定性研究 % ? 生產(chǎn)和質(zhì)量監(jiān)控 % ? 新藥研究申請 IND(Investigational New Drug)和新藥申請 NDA(New Drug Application ) % ? 臨床評價 % ? 其他 % Clinic Phase PreClinic Phase 遭怦枇沐壯餒兔屎豁尖兜均不填嬡
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