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【正文】 cular leak in sepsis in humans[J]. PLoS Med,2006, 3(3): e46.   [14]Calfee CS, Gallagher D, Abbott J, et al. Plasma angiopoietin2 in clinical acute lung injury: prognostic and pathogenetic significance[J]. Crit Care Med, 2012, 40(6): 17311737.   [15]Kumpers P, van Meurs M, David S, et al. Time course of angiopoietin2 release during experimental human endotoxemia and sepsis[J]. Crit Care, 2009, 13(3): R64.   [16]Ricciuto DR, dos Santos CC, Hawkes M, et al. Angiopoietin1 and angiopoietin2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis[J]. Crit Care Med, 2011, 39(4): 702710.   [17]Kumpers P, Lukasz A, David S,et al. Excess circulating angiopoietin2 is a strong predictor of mortality in critically ill medical patients[J].Crit Care, 2008, 12(6):R147.   [18]Luz Fiusa MM, CostaLima C, de Souza GR, et al. A high angiopoietin2/angiopoietin1 ratio is associated with a high risk of septic shock in patients with febrile neutropenia[J].Crit Care, 2013,17(4):R169.   [19]Wang K, Bhandari V, Giuliano JS, et , Angiopoietin2 and Bicarbonate as Diagnostic Biomarkers in Children with Severe Sepsis[J].PLoS One, 2014, 9(9):e108461.   [20]Mammoto T, Jiang A, Jiang E, et al. Plateletrichplasma Extract Prevents Pulmonary Edema through AngiopoietinTie2 Signaling[J].Am J Respir Cell Mol Biol,2014,52(1):5664.   .   [21]Huang YQ, Li JJ, Hu L, Lee M, Karpatkin induces increased expression and secretion of angiopoietin2 from human umbilical vein endothelial cells[J]. Blood, 2002, 99(5):16461650.   [22]Ziegler T, Horstkotte J, Schwab C, et al. Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis[J].J Clin Invest. 2013, 66549[Epub ahead of print].   [23]Bhandari V, ChooWing R,Harijith A,et hyperoxiainduced lung injury in nitric oxide synthase 2 null mice is mediated via angiopoietin 2[J]. Am J Respir Cell Mol Biol, 2012, 46(5):668676.   [24]Stiehl T, Thamm K, Kaufmann J,et al. Lungtargeted RNA interference against angiopoietin2 ameliorates multiple organ dysfunction and death insepsis[J].Crit Care Med, 2014, 42(10):e654662.   [25]Gores KM, Delsing AS, Kraus SJ,et angiopoietin
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