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Angiopoietin1 and angiopoietin2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis[J]. Crit Care Med, 2011, 39(4): 702710. [17]Kumpers P, Lukasz A, David S,et al. Excess circulating angiopoietin2 is a strong predictor of mortality in critically ill medical patients[J].Crit Care, 2008, 12(6):R147. [18]Luz Fiusa MM, CostaLima C, de Souza GR, et al. A high angiopoietin2/angiopoietin1 ratio is associated with a high risk of septic shock in patients with febrile neutropenia[J].Crit Care, 2013,17(4):R169. [19]Wang K, Bhandari V, Giuliano JS, et , Angiopoietin2 and Bicarbonate as Diagnostic Biomarkers in Children with Severe Sepsis[J].PLoS One, 2014, 9(9):e108461. [20]Mammoto T, Jiang A, Jiang E, et al. Plateletrichplasma Extract Prevents Pulmonary Edema through AngiopoietinTie2 Signaling[J].Am J Respir Cell Mol Biol,2014,52(1):5664. . [21]Huang YQ, Li JJ, Hu L, Lee M, Karpatkin induces increased expression and secretion of angiopoietin2 from human umbilical vein endothelial cells[J]. Blood, 2002, 99(5):16461650. [22]Ziegler T, Horstkotte J, Schwab C, et al. Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis[J].J Clin Invest. 2013, 66549[Epub ahead of print]. [23]Bhandari V, ChooWing R,Harijith A,et hyperoxiainduced lung injury in nitric oxide synthase 2 null mice is mediated via angiopoietin 2[J]. Am J Respir Cell Mol Biol, 2012, 46(5):668676. [24]Stiehl T, Thamm K, Kaufmann J,et al. Lungtargeted RNA interference against angiopoietin2 ameliorates multiple organ dysfunction and death insepsis[J].Crit Care Med, 2014, 42(10):e654662. [25]Gores KM, Delsing AS, Kraus SJ,et angiopoietin 2 concentrations are related to impaired lung function and organ failure in a clinical cohort receiving highdose interleukin 2 therapy[J].Shock, 2014, 42(2):115120. ?。ㄊ崭迦掌冢?0150106) ?。ū疚木庉嫞汉涡≤姡? p128132。lt。gt。gt。CoxVBody CVXo6o是一種Ang2特異性拮抗劑,此藥目前正在進行Ⅱ期臨床試驗,評估其療效及其有效治療劑量。gt。gt。Ang2不僅是一個膿毒血癥診斷指標,同時也是誘發(fā)器官損傷的重要介質(zhì)。lt。gt。gt。gt。lt。/supamp。 4Ang在膿毒癥中的作用 目前我們面臨主要問題是缺乏對膿毒癥早期診斷及其預測其疾病發(fā)展的臨床生化檢驗指標。[12]amp。[11]amp。[10]amp。gt。接下來的研究證明Ang3和Ang4