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【正文】 Effective for both low growth fraction malignacies, ., solid tumors, as well as high growth fraction malignancies Overview Treatment regiment and scheduling: ? log kill ? pharmacologic sanctuaries Treatment protocols: ? binations of drugs。 ? treatment protocols Overview Problems of chemotherapy: ? Resistance ? Multidrug resistance ? Toxicity ADP+Pi ATP Medicine Medicine a. mon adverse effects b. duration of adverse effects c. minimizing adeverse effects Antimetabolites ? Folic acid Antagonists: MTX ? Purine Antagonists: 6MP 6TG ? Pyrimidine Antagonists: 5FU araC HU S phase (cellcycle) specific Antimetabolites ? Methotrexate (MTX)
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