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a molecule called an inducer inactivates the repressor and turns on transcription ? The classic example of an inducible operon is the lac operon, which contains genes coding for enzymes in hydrolysis and metabolism of lactose LE 1822a DNA lacl Regulatory gene mRNA 5? 3? RNA polymerase Protein Active repressor No RNA made lacZ Promoter Operator Lactose absent, repressor active, operon off LE 1822b DNA lacl mRNA 5? 3? lac operon Lactose present, repressor inactive, operon on lacZ lacY lacA RNA polymerase Polycistronic mRNA Protein Allolactose (inducer) Inactive repressor ?Galactosidase Permease Transacetylase 5? Copyright 169。 2022 Pearson Education, Inc. publishing as Benjamin Cummings Repressible and Inducible Operons: Two Types of Negative Gene Regulation ? A repressible operon is one that is usually on。 2022 Pearson Education, Inc. publishing as Benjamin Cummings Operons: The Basic Concept ? In bacteria, genes are often clustered into operons, posed of – An operator, an “onoff” switch – A promoter – Genes for metabolic enzymes ? An operon can be switched off by a protein called a repressor ? A corepressor is a small molecule that cooperates with a repressor to switch an operon off LE 1821a Promoter Promoter DNA trpR Regulatory gene RNA polymerase mRNA 3? 5? Protein In