從基因組學(xué)、系統(tǒng)生物學(xué)到轉(zhuǎn)化醫(yī)學(xué)-高血壓發(fā)病機(jī)制研究趨向-文庫吧資料
2024-10-07 15:09本頁面
【正文】 險因素 的作用下，血管壁 氧化應(yīng)激、慢性炎癥、脂質(zhì)沉積、 加速血管老化 Nilsson PM, Laurent S, et al. Hypertension 2020。疾病進(jìn)展與 心血管功能和結(jié)構(gòu)異常 密切相關(guān)，進(jìn)而引起心臟、腎臟、大腦、血管和其它靶器官損害，導(dǎo)致過早發(fā)生心血管事件和死亡。11:611614. 高血壓是一個由多種復(fù)雜和相關(guān)因素導(dǎo)致的、逐漸進(jìn)展的 心血管綜合征 。121:929933 T1: Connecting Basic and Clinical Research 基礎(chǔ)： “Omics” 產(chǎn)生的大量資料 , 對疾病的分子、基因和細(xì)胞基礎(chǔ)的認(rèn)識取得 巨大進(jìn)步 挑戰(zhàn)：對大量復(fù)雜的基因型和表型數(shù)據(jù)進(jìn)行整合、 分析和分享，使之發(fā)揮最大作用 T2: Bridging Research and Practice Implementation research takes interventions that are generally accepted as beneficial and addresses their extension or adaptation to specific populations or settings, testing a variety of educational approaches, behavioral techniques, and environmental or anizational strategies. The study populations can e from a variety of settings and other munity settings Lauer MS, et al. Circulation 2020。 Guyton數(shù)學(xué)模型 人體長期血壓調(diào)控的定量分析 ? 循環(huán)系統(tǒng)調(diào)節(jié)模型 (多變量、非線性的大系統(tǒng)） 400多個生理變量 354個功能塊 18個子系統(tǒng) ? 系統(tǒng)內(nèi)輸入 輸出關(guān)系、反饋關(guān)系用框圖表示 ? 數(shù)字模擬、計算機(jī)分析：接點、常數(shù)、變量上下限，時間常數(shù)，變量間關(guān)系 壓力置定點的調(diào)控：腎臟 Physiology and genomics: toward systems biology The last ten years have seen an unprecedented merge of physiology and genomics. While the field of physiological genomics is still very young, the introduction of the concept of systems biology promises to propel physiological genomics to a whole new level. In this brief article, we outlined some of the great opportunities and challenges for physiologists at this exciting time of physiological sciences, and used our own experience from the last ten years as an example to discuss how we could expand and go beyond the bination of physiology and genomics to achieve a systems understanding of biology. Cowley A. Acta Physiologica Sinica, 2020, 58 : 14 生理學(xué)與基因組學(xué) 走向系統(tǒng)生物學(xué) 國內(nèi)高血壓機(jī)制系列性研究舉例 ? geic study (association study, GWAS) ? RAS (Ang II receptor, ACE2) ? vascular remodeling ? Capsaicin/TRPV1 Channel ? renal dopamine receptor GRK4 ? EETs ? TRP/KYN pathway ? H2S From Bench to Bedside, From Bedside to Community T1, is “the transfer of new understandings of disease mechanisms gained in the laboratory into the development of new methods for diagnosis, therapy, and prevention and their first testing in humans.” T2, is “the translation of results from clinical studies into everyday clinical practice and health dec
教學(xué)課件相關(guān)推薦
鄂ICP備17016276號-1