從基因組學、系統(tǒng)生物學到轉化醫(yī)學-高血壓發(fā)病機制研究趨向-文庫吧資料
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【正文】 險因素 的作用下，血管壁 氧化應激、慢性炎癥、脂質沉積、 加速血管老化 Nilsson PM, Laurent S, et al. Hypertension 2020。疾病進展與 心血管功能和結構異常 密切相關，進而引起心臟、腎臟、大腦、血管和其它靶器官損害，導致過早發(fā)生心血管事件和死亡。11:611614. 高血壓是一個由多種復雜和相關因素導致的、逐漸進展的 心血管綜合征 。121:929933 T1: Connecting Basic and Clinical Research 基礎： “Omics” 產生的大量資料 , 對疾病的分子、基因和細胞基礎的認識取得 巨大進步 挑戰(zhàn)：對大量復雜的基因型和表型數(shù)據(jù)進行整合、 分析和分享，使之發(fā)揮最大作用 T2: Bridging Research and Practice Implementation research takes interventions that are generally accepted as beneficial and addresses their extension or adaptation to specific populations or settings, testing a variety of educational approaches, behavioral techniques, and environmental or anizational strategies. The study populations can e from a variety of settings and other munity settings Lauer MS, et al. Circulation 2020。 Guyton數(shù)學模型 人體長期血壓調控的定量分析 ? 循環(huán)系統(tǒng)調節(jié)模型 (多變量、非線性的大系統(tǒng)） 400多個生理變量 354個功能塊 18個子系統(tǒng) ? 系統(tǒng)內輸入 輸出關系、反饋關系用框圖表示 ? 數(shù)字模擬、計算機分析：接點、常數(shù)、變量上下限，時間常數(shù)，變量間關系 壓力置定點的調控：腎臟 Physiology and genomics: toward systems biology The last ten years have seen an unprecedented merge of physiology and genomics. While the field of physiological genomics is still very young, the introduction of the concept of systems biology promises to propel physiological genomics to a whole new level. In this brief article, we outlined some of the great opportunities and challenges for physiologists at this exciting time of physiological sciences, and used our own experience from the last ten years as an example to discuss how we could expand and go beyond the bination of physiology and genomics to achieve a systems understanding of biology. Cowley A. Acta Physiologica Sinica, 2020, 58 : 14 生理學與基因組學 走向系統(tǒng)生物學 國內高血壓機制系列性研究舉例 ? geic study (association study, GWAS) ? RAS (Ang II receptor, ACE2) ? vascular remodeling ? Capsaicin/TRPV1 Channel ? renal dopamine receptor GRK4 ? EETs ? TRP/KYN pathway ? H2S From Bench to Bedside, From Bedside to Community T1, is “the transfer of new understandings of disease mechanisms gained in the laboratory into the development of new methods for diagnosis, therapy, and prevention and their first testing in humans.” T2, is “the translation of results from clinical studies into everyday clinical practice and health dec
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