武漢大學(xué)分子生物學(xué)全部課程3(參考版)
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【正文】 Wele Each of You to My Molecular Biology Class Molecular Biology of the Gene, 5/E Watson et al. (2023) Part I: Chemistry and Geics Part II: Maintenance of the Genome Part III: Expression of the Genome Part IV: Regulation Part V: Methods 3/08/05 Part II: Maintenance of the Genome Dedicated to the structure of DNA and the processes that propagate, maintain and alter it from one cell generation to the next Maintenance of the Genome Ch 6: The structures of DNA and RNA Ch 7: Chromosomes, chromatins and the nucleosome Ch 8: The replication of DNA Ch 9: The mutability and repair of DNA Ch 10: Homologous rebination at the molecular level Ch 11: Sitespecific rebination and transposition of DNA 3/08/05 CHAPTER 6 The Structures of DNA and RNA How do the structures of DNA and RNA account for their functions? OUTLINE Structure Topology Structure DNA STRUCTURE DNA STRUCTURE (1) DNA is posed of polynucleotide chains Structure: twisting around each other in the form of a double helix. Schematic model Spacefilling model Nucleoside Nucleotide, the fundamental building block of DNA glycosidic bond phosphoester bond DNA polarity: is defined by the asymmetry of the nucleotides and the way they are joined. Phosphodiester linkages: repeating, sugarphosphate backbone of the polynucleotide chain Bases in DNA purines pyrimidines adenine guanine cytosine thymine N9 N1 DNA STRUCTURE (2) Each bases has its preferred tautomeric form (Related to Ch 9) The two strands of the double helix are held together by base pairing in an antiparallel orientation, Which is a stereochemical consequence of the way that adenine and thymine,and guanine and
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